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《Journal of Public Health and Preventive Medicine》 2009-02
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Preliminary study on the DNA-protein crosslinks induced by Butyl Benzyl Phthalate(BBP) in Hela cells

FANG Fang,TANG Bei,HUANG Si-jia,CHANG Qing,WU Dan,GUO Jing,YUAN Jun-lin,YANG Xu College of Life Sciences,Central China Normal University,Wuhan 430079,China  
Objective To study the genetic toxicity of Benzyl Butyl Phthalate(BBP).Methods We exposed the Hela cells in vitro to different concentrations of BBP(0,5,25,125,625 μmol·L-1) for 2 h,the KCl-SDS precipitation assay were used to measure the DNA-protein cross-linking effect.Results All the different concentrations of BBP could cause the increase of DPC coefficient in Hela cells,but this effect was not significant(P0.05) at low concentrations(5 μmol·L-1);while in high concentration(25,125,625 μmol·L-1),BBP induced Hela cells could produce DNA-protein cross-linking effect significantly(P0.01,P0.05).Conclusion Butyl Benzyl Phthalate(BBP) could induce DNA-protein crosslink.
【Fund】: 国家科技部建设部科技支撑计划项目建筑室内生物污染物控制与改善关键技术研究(No.2006BAJ02A10)
【CateGory Index】: R114
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