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《Journal of Public Health and Preventive Medicine》 2012-06
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Surveillance on abnormal reaction following immunization in Nanning(2008-2011)

TANG Jin-fang*,LIANG Zheng-tie,WU Feng-hong,SU Lei-jing,WU Hai-yan *Nanning Center of Disease Control and Prevention,Nanning 530028,China  
Objective To analyze the features of adverse effects following immunization in Nanning from 2008 to 2011.To evaluate the implementation of AEFl surveillance system and the safety of vaccines.Methods The AEFI data of Nanning during the period of 2008-2011 were collected through the National AEFI Information System.Descriptive methodology was used in this study.Results A total of 578 AEFI cases were reported during the period of 2008-2011.Among them,252 cases with general reaction,accounted for 43.60%,280 cases with vaccine paradoxical reaction,accounted for 48.44%,31 cases with coincidental illness,accounted for 5.36%,6 cases with operational error,accounted for 1.04%.336 cases were under 1 year old,accounted for 58.13%.456 cases occurred with aggregation tendency during the period between March and October,accounted for 78.90%.25 kinds of vaccines were involved in AEFI cases,26.99% of AEFI cases were induced by BCG vaccine,20.24% of AEFI cases were induced by DTwP vaccine,15.40% of AEFI cases were induced by MV vaccine;382 cases appeared after the 1st dose,accounted for 66.09%;The reported incidence of AEFI were estimated as 0.28-101.63 per one hundred thousand doses.Conclusions According to the data of surveillance,the AEFI surveillance system of Nanning was operating normally,safety of vaccines and quality of immunization service were fine.AEFI cases were mainly distributed in the low-age children,NIP vaccines,first-dose and in the early period of vaccination.Considering the above factors: surveillance on the privately purchased vaccination should be strengthened;personnel training should be promoted;,regular AEFI supervision should be carried out so as to ensure the quality of AFEI surveillance.
【CateGory Index】: R186
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