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Cytotoxicity of Autonomous Parvoviral Non structural Protein NS1 to Transformed Cells and the Mechanism in Its Regulation of DNA Replication and Transcription

LUO Zu yu,SHI Zhi yi,LIN Wan min (Department of Physiology and Biophysics)  
Autonomous parvovirus has transformed cell specific toxicity. Its non structural protein NS1 plays an important role in the process of cytotoxic action. In parvoviral life cycle NS1 regulates DNA replication and transcription. The possible molecular mechanisms include trans inhibition of DNA replication,trans inhibition of gene expression and trans activation of transcription.
【Fund】: 国家自然科学基金
【CateGory Index】: Q939.4
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