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《Journal of Fudan University(Natural Science)》 2007-06
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An in vitro study on the genetic toxicology of Single Prescription Fuctus Aritolochiae and Compound Prescription Long Dan Xie Gan Wan,both containing Aristolochic Acid

MA Kang-mu1,CHEN Ling2 (1.School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China;2.Shanghai Jiaotong University,College of Life Science and Technology,Shanghai 200240,China)  
To detect the different mutagenicities,cytotoxicities of Fructus Aristolochiae(FA) and Long-Dan-Xie-Gan-Wan(LDXGW),single and compound prescriptions in Chinese Traditional Medicine(CTM) respectively,via the means of Ames Test and Mouse Lymphoma Assay(MLA).The mutation frequency caused by FA and LDXGW,which contained Aristolochic Acid(AA) with the concentration of 20 μg/mL and 40 μg/mL in two tests,were detected by conducting the normal Ames tests,with or without S9 added.MLA: L5178Y tk+/——3.7.2c cells were treated with FA and LDXGW,with the concentration of AA as 5 μg/mL.The plating efficiency(PE),relative total growth(RTG) and the mutant frequency(MF) were detected by the microtiter procedure.FA is characterized by marked cytotoxicity and mutagenic activity.Its mutagenicity may result in large range of DNA damage;while LDXGW shows that CTM's cytotoxicity and mutagenic activity might be largely reduced when made into a compound.MLA is much more sensitive than Ames Test in genetic toxicity test.The virtue of the combination of two methods was explored at the first trail.
【Fund】: 国家自然科学基金资助项目(30472110)
【CateGory Index】: R285
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