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《Journal of Chongqing University(Natural Science Edition)》 2005-06
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Research Progress of Matrine and Oxymatirne in the Anti-tumor Mechanism

SHEN Xiao-dong, SONG Guan-bin, YAN Run-bin, YANG Yang (Key Laboratory for Biomechanics and Tissue Engineering Under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China)  
The Matrine and Oxymatirne are two kinds of alkaloid, and have many kinds of pharmacological functions. In recent years, their anti-tumor mechanism has been paid more attention. This article is a summarization of the research progress of Matrine and Oxymatirne in the anti-tumor mechanism. Now people have found out that the Matrine and Oxymatirne can restrain the multiplication of tumor cells via restrainning the synthesizatinon of DNA and the enzyme activity and effectting the normal cycle, and they also can restrain the transfer of the tumour via controlling the expression of the genes, and induce the death of the tumour cell and induce the tumour cell to differentiate into the common cell via controlling the expression of the genes and effecting the telomerase activity.
【Fund】: 国家自然科学基金资助项目(19972077)
【CateGory Index】: R730.5
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