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《Journal of Chongqing University》 2009-05
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Biological toxicity effect of CO in fire smoke

LIU Fanga,b,ZHU Weia,WANG Gui-xueb(a.Faculty of Urban Construction and Environmental Engineering,b.Faculty of Biology Engineering,Chongqing University,Chongqing 400030,P.R.China)  
We investigate the effect of CO on the blood rheology parameters and blood gas composition.Experiments are conducted under isothermal toxicity gas concentration non-radioactive conditions.We use an exposure box 0.8 m long,0.5 m wide,and 0.5 m high.CO produced by the chemical reaction of formic acid and dense sulphuric acid is introduced to the box by an air-sampling pump.After completion of the exposure period,the blood samples are removed from the animal.The toxicity exposure experiment indicates that after inhaling the CO,the exposed rabbit exhibits signs of metabolized respiratory alkaline toxicosis.While the rabbit inhales CO,the blood gas parameters values of PCO2,TCO2 and HCO3-increase;PO2 reduces very noticeably;and the rheology parameters of whole blood viscidity are higher than the normal values.The viscidity will be higher if the exposure is longer,a very obvious change,especially at low rheology velocity.
【Fund】: 教育部科学技术研究重点资助项目(104158);; 国家自然科学基金重点资助项目(50838009)
【CateGory Index】: X928.7
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