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《Journal of Fujian Medical University》 2001-02
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The Protective Effect of Sagittaria Sagittifolia Against Cadmium-mediated Acute Liver Damage

LU Zu-fu+1, HUANG Fang+2, WANG Jia-li+3, et al (1.99 Postgraduate, 2.Department of Nutrition and Maternity and Child Hygiene, 3.Department of Basic Laboratory Public Health College, Fujian Medical University, Fuzhou 350004, China)  
Objective\ To study the hepatoprotective effect of Sagittaria Sagittifolia against cadmium\|mediated acute liver damage.\ Methods\ 48 Kunming male one\|month\|old rats(divided into 6 groups randomly) were used for this experiment.\ After cadmium was given for five consecutive days,the concentration of serum LPO, SOD, CP and the content of liver Cd, GSH were measured in each group above, and the liver sections were examined pathologically also.\ Results\ The concentration of serum LPO in the groups treated with Sagittaria Sagittifolia(12 22±2 09, 13 47± 2 68, 12 13±3 01) was lower than that of the positive control(18 03±3 56), the liver GSH content(4 83±0 44, 5 08±0 41, 5 22±0 39) was higher than that of positive control(4 01±0 67), and the liver pathologic damage induced by cadmium was also alleviated.\ There was positive correlation between the liver cadmium content and the serum LPO concentration(r=0.6563,P0.01).\ Conclusion\ Sagittaria Sagittifolia possesses protective effect against the cadmium\|mediated acute liver damage.\;
【Fund】: 福建省教育厅科研基金项目! ( JA99179)
【CateGory Index】: R285.5
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