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《Journal of Fujian Medical University》 2001-04
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The Association of E-selectin Gene S128R Polymorphism with Coronary Artery Disease

LIN Fan, ZHUANG Wei\|te, LIN Li\|xiang (Department of Endocrinology, Fujian Province Hospital, Fuzhou 350001, China)  
Objective\ To investigate the association of E\|selectin S128R polymorphism with coronary artery disease(CAD).\ Methods\ Genomic DNA was extracted from peripheral blood leukocytes in 92 CAD patients and 85 control subjects.\ DNA was amplified by polymerase chain reaction(PCR).\ PCR product was digested with the restriction enzyme PstⅠ and separated on 2% agarose gel electrophoresis.\ Concentrations of plasma soluble E\|selectin were estimated using the ELISA kits in 36 CAD patients and 29 control subjects.\ Results\ The frequency of R allele in CAD patients was significantly higher than that in controls(11 96% vs 4 71%, P0 05).\ E\|selectin levels was related to E\|selectin genotype, being higher in subjects possessing the R allele(33 23±7 20 vs 22 58±8 28 ng/ml, P0 05).\ Conclusion\ E\|selectin S128R polymorphism is associated with CAD and R allele may be a risk factor for CAD, involved in the onset of CAD with other risk factors such as high triglyceride and systolic pressure.
【CateGory Index】: R541.4
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