Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Fujian Medical University》 2002-03
Add to Favorite Get Latest Update

The Change of Vascular Endothelial Growth Factor and Nitric Oxide in the Retina of Diabetic Rats

CHEN Shao\|qiang, CHEN Rui\|hua, HUANG Yan, et al (Division of Anatomy and Histology and Embryology, Fujian Medical University, Fuzhou\ 350004, China) \ \  
Objective\ To investigate the change of vascular endothelial growth factor(VEGF) and nitric oxide(NO) in the retina of diabetic rats and their effect on the pathogenesis of diabetic retinopathy.\ Methods\ Healthy adult SD rats were chosen and divided into normal contrast group, diabetes mellitus one month(DM1), three\|month(DM3) and five\|month(DM5) groups.\ Diabetic rats were induced by streptozotocin(STE) intraperitoneally.\ The expression of VEGF in the retina of all group of rats were observed by immunohistochemistry, the activity of nitric oxide synthase(NOS) and quantity of NO in the retina of all groups of rats were examined.\ Results\ At 3 months of diabetic course, the expression of VEGF, activity of NOS and quantity of NO in the retina of diabetic rats increased significantly.\ At 5 months of diabetic course, the expression of VEGF in the retina of DM5 rats was higher than DM3, but activity of NOS and quantity of NO in the retina of DM5 rats was lower than DM3.\ Conclusion\ The over\|expression of VEGF and decrease of activity of NOS and contents of NO in the retina of diabetic rats played an important role in diabetic retinopathy.\;
【Fund】: 福建省自然科学基金资助项目 (C9810 0 3 4)
【CateGory Index】: R587.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 Chen Haiying ,Liao Lihong , Chen Jianming Depat of Basic Medicine, Putian Universty,Putian,Fujian;Changes of Endostatin and VEGF in Retina of Diabetic Rats and Protection of Tetromethylpragine on Them[J];Journal of Changzhi Medical College;2006-03
2 CHEN Qun,LIU Jing-fengDepartment of General Surgery,The Affiliated First Hospital,Fujian Medical University,Fuzhou 350005,China;Changes and Significance of the Serum Nitric Oxide Level and NOS Activity in Diabetic Rats[J];Journal of Fujian Medical University;2005-04
【Citations】
Chinese Journal Full-text Database 2 Hits
1 HUANG Yan, CHEN Shao\|qiang, CHEN Rui\|hua, et al (Department of Anatomy, Fujian Medical Uiniversity, Fuzhou\ 350004, China)\;;Protective Effect of Tetramethylprazine on the Free Radical Retinal Damage in Diabetic Rats[J];Journal of Fujian Medical University;2001-02
2 Liu Xuezheng,Xiao Hong,Pang Dongbo,Li Ruixiang (Department of Anatomy,Jinzhou Medical College,Jinzhou 121001);ULTRASTRUCTURAL CHANGES OF RETINAL CAPILLARIES AND PHOTORECEPTORS IN EARLY DIABETIC RATS[J];Chinese Journal of Anatomy;2001-04
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 HUANG Yan, CHEN Shao\|qiang, CHEN Rui\|hua, et al (Division of Anatomy and Histology and Embryology, Fujian Medical University, Fuzhou\ 350004, China)\;;Effect of Tetramethylprazine and Aminoguanidine on Aldoes Reductase Activity of the Retinal Tissue of Diabetic Rats[J];Journal of Fujian Medical University;2002-03
2 CHEN Qun,LIU Jing-fengDepartment of General Surgery,The Affiliated First Hospital,Fujian Medical University,Fuzhou 350005,China;Changes and Significance of the Serum Nitric Oxide Level and NOS Activity in Diabetic Rats[J];Journal of Fujian Medical University;2005-04
3 Huang Zhaowei, Xu Shanqi, Jiao Xi-aoyang, et al. First Affiliated Hospital, Medical College Shantou University, Shantou, 515041;Study of cell - mediated immunal function in patients with diabetic retinopathy[J];Guangdong Medical Journal;2005-08
4 Chen Shaoqiang , Huang Yan, Chen Ruihua, Zhang Geng (Department of Anatomy, Fujian Medical University, Fuzhou 350004, China);EFFECT OF TREATMENT WITH TETROMETHYLPRAGINE AND AMINOGUANIDINE ON VEGF IN THE RETINA OF DIABETIC RATS[J];Chinese Journal of Histochemistry and Cytochemistry;2002-03
5 Yong-Sheng Chen Department of Ophthalmology,Linyi People's Hospital,Linyi 276003,Shandong Province,China;Clinical research of relation of PEDF,TNF-α and adiponectin with type 2 diabetic retinopathy[J];International Journal of Ophthalmology;2009-09
6 CHEN Shao Qiang, CHEN Rui Hua, HUANG Yan, ZHANG Geng (Department of Anatomy,Fujian Medical University,Fuzhou 350004,China);Correlation between ultrastructural changes of visual cells and aldose reductase in retina of early diabetic rats and protection of Aminoguanidine on them[J];Chinese Journal of Anatomy;2002-05
7 CHEN Rui Hua 1, HUANG Yan 1, CHEN Shao Qiang 1, CHEN Zhen Bin 2 ZHANG Geng 1, YU Xiu Ping 1, ZHU Xue Jun 3 ( 1Department of Anatomy,Fujian Medical University, 2Department of EM,Fujian Medical University, 3First Affiliated Hospital of Fujian Medical University,Fuzhou 350004,China);Ultrastructure of retinal pigment epithelium in diabetic rats[J];Chinese Journal of Anatomy;2002-05
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 Zhuo Wenjing,Wang Zhongshan,Xu Zongge,et al(Laboratory of Cell Biology);Study of reproductive method on diabetic model in puberty rats[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1995-02
2 LIU Zhi Yong 1, HAN Li Rong 1, ZHANG Chuan Sen 2, HAN Chuan Gui 1 (1. Department of Ophthalmology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2. Department of Anatomy, Department of Basic Medicine) [;Remodeling of retinal microvessels in STZ-induced diabetic rats and medical influence[J];Academic Journal of Second Military Medical University;2000-12
3 Zheng Hui 1, Wang Zhongxin 2, Wu Changzhu 1, et al (1 Department of Biochemistry, Fujian Medical University, Fuzhou, 350004 2 Department of Endocrine, The Affiliated 1st Hospital, Fujian Medical University, Fuzhou, 350005) \;;Circulating Nitric Oxide,Lipid Peroxide and Superoxide Dismutase in Patients with Diabetes Mellitus Type Ⅱ and its Clinical Significance[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;1999-04
4 Deng Juan,Qi Chaoxiu,Li Qunyin,et al.Department of Ophthalmology,the Third Affiliated Hospital of Sun-Yat Sen University of Medical Science,Guangzhou 510630;Detection of electroretinogram oscillatory potentials and color vision in patients with diabetic retinopathy in early stage[J];Journal of Clinical Ophthalmology;2001-05
5 XUE Cai-ping,YUAN Xiao-ru(Department of Physiology, NJMU, Nanjing 210029, China);A Study on Effects of Alcohol on Pattern Reverse Electroretinogram and Visual Evoked Potetial of Rats[J];Acta Academiae Medicinae Nanjing;2003-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Zhong Meifang,Hu Jinjia,Ding Wenlong**,Gu Hongyu Department of Anatomy,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China;Effect of insulin on the treatment of rats with diabetic erectile dysfunction[J];Chinese Journal of Andrology;2007-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved