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《Journal of Fujian Medical University》 2002-04
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Effect of Acute Ischemia on L-type Calcium Channal Current in Isolated Guinea Pig Ventricular Myocytes

WU Li\|ming, TANG\|Ming (Department of Emergency, The Affiliated Union Hospital, Fujian Medical University, Fuzhou\ 350001, China)\ \  
Objective\ To investigete the effect of acute ischemia on the L\|type Ca\+\{2+\} channel current(I\-\{Ca\|L\}) in guinea pig ventricular myocytes.\ Methods\ Using the technique of whole cell patch clamp to determine basaline and 5, 10, 15 and 20 min after acute myocardial ischemia for detection of the effect of the L\|type Ca\+\{2+\} channel current in isolated guinea pig ventricular myocytes.\ Results\ The peaks of I\-\{Ca\|L\} were decreased obviously by 25 65%±4 29% compared with the control group during acute ischemia(P0 05); but there was no any significant changes on maxium active voltage and I\-\{Ca\|L\} I\|V relation curve.\ Conclusion\ The I\-\{Ca\|L\} in isolated guinea pig ventricular myocytes is inhibited prominiently by acute \{ischemia\}; and there is no influence to maxium active voltage and I\-\{Ca\|L\} I\|V relation curve.\;
【CateGory Index】: R541.02
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【References】
Chinese Journal Full-text Database 2 Hits
1 WU Li\|ming, TANG Min (Department of Emergency, The Affiliated Union Hospital, Fujian Medical University, Fuzhou\ 350001, China)\;;Effects of Endothelin-1 on L-type Calcium Current in Guinea Pig Ventricular Myocytes during Acute Ischemia[J];Journal of Fujian Medical University;2003-01
2 WU Li-Ming, and TANG Ming ( Department of Emergency, the Union Hospital, Fujian Medical University, Fuzhou, 350001, China);Inhibition of Tumor Necrosis Factor-aon L-type Calcium Current in Guinea Pig Ventricu- lar Myocytes accmpany simulation of Acute Ischemia[J];Chinese Journal of Arterial Lerosis;2004-03
【Citations】
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1 ZHOU Jing,REN Zi wen,ZHANG Jun hua,et al (First Hospital of Beijing University,Beijing 100034,China);Influence of taurine on inhibitory effect of urotensin II on L-type calcium current[J];Editorial Departmert of Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease;2002-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 WU Li\|ming, TANG Min (Department of Emergency, The Affiliated Union Hospital, Fujian Medical University, Fuzhou\ 350001, China)\;;Effects of Endothelin-1 on L-type Calcium Current in Guinea Pig Ventricular Myocytes during Acute Ischemia[J];Journal of Fujian Medical University;2003-01
2 WU Li-Ming, and TANG Ming ( Department of Emergency, the Union Hospital, Fujian Medical University, Fuzhou, 350001, China);Inhibition of Tumor Necrosis Factor-aon L-type Calcium Current in Guinea Pig Ventricu- lar Myocytes accmpany simulation of Acute Ischemia[J];Chinese Journal of Arterial Lerosis;2004-03
3 WANG Ling-fang,YIN Yong-qiang,ZHAO Lin,WU Hong,KANG Yi,LOU Jian-shi (Department of Pharmacology,Tianjin Medical University,TIANJIN 300070,China);Effects of taurine-magnesium coordination compound on calcium channel in rat cardiomyocytes of arrhythmia induced by aconitine[J];Chinese Journal of New Drugs and Clinical Remedies;2011-01
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10 Gao Fenfei,Huang Zhanqin,Zhou Yanqiong,et al.(Department of Pharmacology,Medical College of Shantou University,Guangdong,Shantou 515041 China);IMPROVEMENT OF MYOCARDIAL CELL ISOLATION AND OBSERVATION OF POTASSIUM CURRENT[J];Journal of Guangxi Medical University;2008-03
【Secondary References】
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【Secondary Citations】
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1 CHEN Yahong *, ZHAO Mingwu, XIA Chunfang, et al. *Respiratory Department, Third Hospital, Beijing University, Beijing 100083, China;Effect of urotensin Ⅱ on the airway smooth muscle cell proliferation and its mechanism[J];National Medical Journal of China;2000-12
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