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《Journal of Fujian Medical University》 2003-02
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Expression of Thymidylate Synthase in Gastric Carcinoma and its Clinicopathological Significance

ZHUO Li\|juan\+1, SHI Zuo\|lin\+2, GAO Mei\|qin\+1, LI Yan\|hui\+2, ZHENG Wei\+1 1.Division of Pathology, Fujian Medical University, Fuzhou 350004, China 2.Department of Pathology, Fujian Province Hospital, Fuzhou 350001, China  
Objective To observe the expression of thymidylate synthase(TS) in gastric \{carcinoma\} and its relationships with clinicopathological characteristics and prognosis. Methods TS expression in 70 cases of gastric carcinoma and 30 cases of normal gastric mucosa was assessed by immunohistochemical staining technique and computer imaging analysis technique. Results The expression TS level of in normal gastric mucosa was higher than that in gastric carcinomas. The level of TS in well\|\{differentiated\} gastric carcinomas was higher than that in poor\|differentiated cases. There was an inverse association between the level of tumor TS expression and clinical prognosis. The level of TS showed no correlation with age, sex and lymph node metastases. Conclusion The expression of TS can serve as a 5\|FU\|based chemotherapeutic efficacy index in patients with gastric carcinoma.
【CateGory Index】: R735.2
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