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《Journal of Fujian Medical University》 2004-04
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Chitosan-Fluorouracil Preparation and its Releasing Test in vitro

LIN You-wen, JIANG Zhi-qing, ZENG Zhi-bin, ZHANG Wan-chunSchool of Pharmacy, Fujian Medical University, Fuzhou 350004, China  
Objective To prepare carboxymethyl chitosan microspheres of fluorouracil(FU-CMCS-MS), and measure the releasing of FU-CMCS-MS in vitro. Methods FU-CMCS-MS was prepared by cross-linking-emulsion method. The surface structure of chitosan-fluorouracil preparation were checked with IR spectra and SEM photography. Grain size distribution of the micropheres was analysed. The releasing of FU-CMCS-MS were investigated in simulated gastric solution(pH 1.22), enteric fluid(pH 7.01) and simulated colon fluid(pH 7.45), respectively. Results The SEM photos group showed that the surface of FU-CMCS-MS was regular, smooth and dense. The diameter of the 60% of micropheres were about 2~15 μm. The drug content of micropheres was 8.39%(W/W). Sustained release of FU-CMCS-MS were observed both in pH 1.22, pH 7.01, pH 7.45 buffer solution. Conclusion Fluorouracil release from FU-CMCS-MS was sustained in different pH condition.
【Fund】: 福建省自然科学基金资助项目 (C0 3 10 0 2 4)
【CateGory Index】: R943
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