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《Journal of Fujian Medical University》 2010-03
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The Evaluation of Curcumin Self-microemulsifying Delivery System in vivo and in vitro

WU Xuemei 1,2,ZHANG Jing3,XU Jianhua1,4,HUANG Xiuwang1,SONG Hongtao3,WENG Caixia11.Clincal Pharmacology Institute of Fujian Medical University,Fuzhou 350001,China;2.The Affiliated Union Hospital,Fujian Medical University,Fuzhou 350001,China;3.Fuzhou General Hospital,Fuzhou 350025,China  
Objective To prepare the curcumin self-microemulsifying delivery system and to evaluate the quality in vivo and in vitro.Methods The pH,self-emulsification time,particle size,morphology,stability and dissolution of the resultant emulsion after self-emulsifying were determined.The plasma concentrations were determined by HPLC and the pharmacokinetics behavior of curcumin microemulsion was evaluated by comparison with suspension.Results The curcumin self-microemulsifying delivery system can emulsified completely within 4 min.Mean particle size of the resultant emulsion was 31.98 nm,and pH approximated to neutral.The dissolution of curcumin self-microemulsifying formulation at 10 min was 100% and the content of drug maintained above 94% with 8 h.Compared with suspension,the area under time-concentration curve(AUC) of micro-emulsion after gavage increased 12-fold.Conclusion The self-microemulsifying delivery system can significantly increase curcumin dissolution in vitro and bioavailability in vivo.
【Fund】: 福建省科技重点项目(2009Y0025)
【CateGory Index】: R283
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