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《Fujian Medical Journal》 2009-06
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Iufluence of peroxisome proliferator-activated receptor γ(PPARγ) ligands on angiogenesis in renal cell carcinoma

Yang Fengguang,Ye Liefu,Lin Le,Li Tao,He Yanyu,Zhang Zhiwen,Guo Yinglu.Department of Urology,Fujian Provincial Hospital,Fuzhou 350001,China  
Objective To investigate the expression of vascular endothelial growth factor(VEGF) induced by peroxisome proliferator-activated receptor γ(PPARγ) in renal cell carcinoma(RCC)-derived cell lines.Methods RT-PCR was performed to determine the VEGF mRNA before and after treatment with 0 and 50 μmol/L TZDs(pioglitazone or troglitazone) for 48 h in two RCC-derived cell lines(786-O and A498).The mutative expressions of VEGF protein were detected by western blot analysis.Results Treatment with 50 μmol/L TZDs(for 48 h) decreased both the VEGF mRNA and protein expression in RCC-derived cells.Conclusion The results reveal that PPARγ ligands involve angiogenesis inhibition on RCC cells.PPARγ may be the candidates target for a novel approach to the treatment of RCC.
【Fund】: 福建省科技人才创新项目(2005J072)
【CateGory Index】: R737.11
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 YANG Feng-guang, SHI Chang-jin, ZHANG Zhi-wen, et al. Department of Urology, Frist Hospital, Peking University, Institute of Urology, Peking University, Beijing 100034, China;Expression of Peroxisome Proliferator-actived Receptor Y in Renal Cell Carcinoma[J];Chinese Journal of Experimental Surgery;2004-09
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Ming-hua1, ZHONG Xue-yun2, LIN Chen-li2, XIE You-ke2, JIA Jin-ping2, LI Su-mei2, MI Can11Department of Pathology, Chongqing Medical Oniversity, Chongqing 410016, China; 2Department of Pathology, Meaical college of Ji'man University, Gnangzhou 510632, China;Expression of peroxisome proliferator-activated receptor γ in glioma[J];Journal of Southern Medical University;2008-03
2 SHU Zhen-bo,CAO Hai-pin,GAI Bao-dong,et al.(Department of Gastroenterology,China-Japan Union Hospital of Jilin University,Changchun 130033,China);Different expression and significance of peroxisome proliferator-activated receptor γ in colorectal cancer[J];Chinese Journal of Laboratory Diagnosis;2008-03
3 HE Kun,HU Ze-ming,ZHOU Zai-ping,CHEN Hong,DENG Hui-zhou The First Department of General Surgery,Zhongshan City People's Hospital (Zhongshan Affiliated Hospital of Sun Yat-Sen University), Zhongshan 528400,China;Different Expression and Significance of PPARγ in Hepatocellular Carcinoma[J];Cancer Research on Prevention and Treatment;2009-12
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Xingpeng,XU Xuanfu,WANG Bingxian,et al.Department of Gastroenterology,Shanghai First People's Hospital,Shanghai 200080,China;Peroxisome proliferator activated receptor γ (PPARγ) is aberrantly expressed in pancreatic carcinoma[J];Chinese Journal of Experimental Surgery;2002-06
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