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《CHINESE JOURNAL OF RHEUMATOLOGY》 2000-02
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Research on source of macrophage in rheumatoid synovium

DAI Lie ,YE Zhiqiang,TANG Meian,et al. Department of Rheumatic Immunology,Third Affiliated Hospital of Sun Yat sen University of Medical Sciences,Guangzhou 510630, China  
Objective To know the source of macrophage in rheumatoid synovium.Methods CD68 and PCNA were detected by immunohistochemical LSAB method on serial synovial sections of 26 cases of RA,20 cases of control non RA and 7 cases of normal synovia.Results The lining cells of normal synovia were almost all CD68 positive and PCNA negative while CD68 and PCNA positive cells in sublining area were scarce;PCNA positive cells in lining and sublining areas of RA synovia were significantly increased ( P 0 05),most lining synoviocytes were CD68 positive and the CD68 positive cells in sublining area were also significantly increased ( P 0 05),some CD68 positive cells in lining and sublining areas of RA synovia were also PCNA positive.Conclusion Both macrophage like synoviocytes and infiltrated macrophages in sublining area of RA synovia have local proliferation.
【CateGory Index】: R593.22
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