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《Chinese Journal of Rheumatology》 2001-03
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Mixture injection of Chinese herbal drugs in the treatment of BXSB mouse systemic lupus erythematosus

ZHAO Guoqing ,XU Shizheng,LI Suping,et al. Department of Dermatology,People′s Hospital of Wchan University,Wuhan 430060,China.  
Objective To investigate the effect of the mixture injection of ruberbs and astrugulars in the treatment of SLE like BXSB mice.Methods Fifteen male and six female BXSB mice at the age of three months were randomly divided into 3 groups:group A was Chinese herb group treated with mixture injection of rhuberb and radix astragali;group B was dexamethasone group;group C was normal saline group.Three groups of BXSB mice were intra abdominal injection every day for six weeks.The levels of proteinuria in different groups of BXSB mice were measured by spectrophotometry.The titers of anti nuclear antibodies (ANA) and the depositions of immunoglobulins in renal glomeruli in all BXSB mice were analysed by immunofluorescence.Results The levels of proteinuria and the titers of serum ANA in group A and in group B mice were lower than in group C ( P 0 01,or P 0 05).The depositions of immunoglobulins in renal glomeruli were the same ( P 0 05).The levels of proteinuria in group A were lower than in group B ( P 0 05).Conclusion The results show that the mixture injection of rhuberb and radix astragali was effective to mouse SLE.
【CateGory Index】: R593.24
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