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《Chinese Journal of Rheumatology》 2003-03
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Effects of cholecystokinin octapeptide-8 on the proliferation of rat fibroblast-like synovial cells and its possible molecular mechanism

JIN Yu huai ,ZHAO Zhan sheng,XU Jin rong,LIU Pin li,LI Shu jin,LING Yi ling,CONG bin. Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China Corresponding author:CONG bin,050017,Department of Pathophysiology,Hebei Medical University,Shijiazhuang,China  
Objective To investigate the effects of cholecystokinin octapeptide (CCK 8) on the proliferation of rat fibroblast like synovial cells in the presence of tumor necrosis factor (TNF) α and its possible molecular mechanism.Methods The effects of CCK 8 on proliferation of rat fibroblast like synovial cells were measured by monotetrazolium (MTT) colourmetric assay and the IL 6 production of the RSC 364 cell line at different concentrations of CCK 8 was detected by enzyme linked immunosorbent assay (ELISA).Results At the concentrations of 10 -6 ,10 -7 and 10 -8 mol/L,CCK 8 significantly inhibited the proliferation of RSC 364 cells and cultured synovial cells of collagen incuced arthritis (CIA) rat in the presence of TNF α,at the concentration of 10 -6 mol/L,CCK 8 stimulated the production of interleukin (IL) 6 of RSC 364 cells,and the stimulating effect of CCK 8 on the IL 6 production was significantly inhibited by CCK receptor antagonist proglumide.Conclusion CCK 8 can inhibit the proliferation of RSC 364 cells and cultured synovial cells of CIA rat in the presence of TNF α and this effect might be mediated by stimulating the IL 6 production.The results suggest that CCK 8 is a possible regulator on the pathogenesis of rheumatoid arthritis.
【CateGory Index】: R593.22
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