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《Chinese Journal of Rheumatology》 2004-12
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An observation on clinical efficacy in fibromyalgia syndrome

JIANG Feng*, LIU Jian-bai. *Department of Rheumatology and Immunology, The Third Hospital of Huzhou, Zhejiang 313000, China  
Objective To compare the efficacy between basic treatment, amitriptyline, and basic treatment combined with mirtazapine and total glucosides of paeonia (TGP) capsule in 4 groups of patients with fibromyalgia syndrome (FS). Methods The change of the pain before the treatment, one-month and three-months (after) treatment were analyzed by Visual Analogue Scale (VAS), Symptom Checklist 90 (SCL-90), Hamilton Anxiety Scale (HAMA), and Hamilton Depression Scale (HAMD). Results ① The scores of SCL-90 in group B was significantly lower than group A (P0.05) at the end of one and three month treatment. ② The dereased values of VAS was significantly lower in group C (P0.05) than group B at the end of one month treatment. ③ The decreased values of VAS. SCL-90 in group D was significantly lower than group A, B and C (P0.05) at the end of one and three month treatment. ④ The changes of scores in HAMA and HAMD used in this study was not consistent with the change of clinical symptoms and signs. Conclusions ① The efficacy will be obviously improved and safer by the basic treatment of fibromyalgia syndrome (FS) employing amitriptyline, by adding low dose mirtazpine. ② Employing SCL-90 in assessing the efficacy of FS may be valuable in comparing changes of symptoms for fibromyalgia patients.③ HAMA and HAMD are not suitable for diagnosis or the efficacy observation of FS.
【CateGory Index】: R593.2
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【Co-citations】
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1 LI Guo-li,CHEN Xie-yun,SUN Jing(TCM university of Hunan,Changsha,Hunan,410007 China);Curative effect of Ercong pill for sudden deafness of Qi-stagnancy and blood stasis[J];Journal of Traditional Chinese Medicine University of Hunan;2008-03
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