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《Chinese Journal of Rheumatology》 2005-01
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Study on B lymphocyte subsets in periphral blood of patients with systemic lupus erythematosus and its relationship with humour immunity

ZHANG Li-jun, LI Bo, ZHONG Li, WANG Xun, LI Jian-song, ZHUANG Jun-han, YE Zhi-zhong. Department of Rheumatology, Xiangmihu Branch of Shenzhen Futian People′s Hospital, Guangdong 518040, China  
Objective To study B lymphocyte subsets in periphral blood of patients with systemic lupus erythematosus (SLE) and its relationship with humour immunity. Methods Blood samples and clinical data from 27 patients were collected. B lymphocyte subsets in periphral blood of patients with SLE were detected by fiow cytometry. The B lymphocyte subsets and its relationship with humour immunity were analyzed. Results The percentage of B1 lymphocyte subsets in periphral blood in patients with SLE and the ratio of B1/B2 lymphocyte subset were higher than those in normal control, and had positive correlation to the level of IgM. In patients with SLE, the percentage of B1 lymphocyte subsets and the ratio of B1/B2 lymphocyte subset were higher in anti-dsDNA-Ab positive group then in anti-dsDNA-Ab negative group. Conclusion B lymphocyte subsets in periphral blood of patients with SLE are abnormal and may play a role in the pathogenesis of SLE were the way of humour immunity.
【CateGory Index】: R593.241
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