Association of killer cell immunoglobulin like receptor (KIR) gene polymorphism with Behcet's disease
XU Ling-di,LU Yu,ZHANG Lei,YANG Jue-qin,YAO Fang-juan,FAN Li-an,Shanghai Institute of Immunology,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China
Objective To investigate whether the killer cell immunoglobulin-like receptor (KIR) gene polymorphism is associated with Behcet's disease (BD). Methods Ninety-five patients with BD in nationality Han in Shanghai area and 87 randomly ethnically matched controls were enrolled to detect the KIR genotype using PCR-SSP. Results The KIR3DL1 gene frequency was significantly lower in patients with BD (0.728) than in the healthy controls (1.00) (RR=0.067, P=0.009). The rest of the gene frequency was found to have no statistically significant difference compared with the healthy controls. Conclusion There may be a negative association between the pathogenesis of BD and KIR3DL1 gene. The function of KIR3DL1 molecule should be investigated further.