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《CHINESE JOURNAL OF RHEUMATOLOGY》 1998-04
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AN ANALYSIS OF RELATIONSHIP BETWEEN THE GENE FREQUENCY OF HLA DR2,DRB1*0301,DQA1*0501 AND THE CLINICAL MANIFESTATIONS AND THE LABORATORY FINDINGS IN PATIENTS WITH PM/DM

Zang Song,Deng Xuexin,Gan Xiaodan,Songhui,Tang Fulin.Department of Rheumatology,Peking Union Medical College Hospital,Beijing,100730.  
Objective:To compare the gene frequencies of HLA DR2、DRB1*0301、DQA1*0501 alleles with the pathogenesis and clinical manifestations of PM/DM.Methods:Thirty one PM/DM patients and 50 healthy control subjects were examined separately by PCR SSP to get the gene frequencies of the three alleles.Results:The gene frequency of HLA DR2 allele (6 45%) was much lower in PM/DM patients than that in normal subjects while the gene frequency of HLA DQA1*0501(77 42%) was much higher,the gene frequency of HLA DRB1*0301 had no difference between the two groups.Conclusion:HLA DR2 may play a protective role in the pathogenesis of PM/DM,while HLA DQA1*0501 is a risk factor of the diseases.
【CateGory Index】: R593.26,
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