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《Journal of Radioimmunology》 2005-04
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Expression of Activation Markers on Lymphocytes in Synovial Fluid From Patients with Rheumatoid Arthritis

Wang Keyi, Yang Chun, Leng Jianhang, et al. Department of Nuclear Medicine, Hangzhou First People’s Hospital, Hangzhou (310006)  
Objective To study the expression of activation markers CD69,CD25,CD71,HLA-DR on synovial fluid lymphocytes in patients with rheumatoid athritis (RA) and to identify their role in the pathogenesis of RA. Methods Cell surface expression of activation markers CD69,CD25,CD71 and HLA-DR on lymphocytes of synovial fluid in 20 patients with RA were studied with flow cytometry and 10 controls. Results The expressions of CD25 and CD71 on lymphocytes in patients’s synovial fluid were significantly higher than those in controls (P0.01). But the expressions of CD69 and HLA-DR were not significantly different (P0.05). Conclusion The over-expression of CD25,CD71 on lymphocytes in synovial fluid of patients with RA may play an important role in the pathogenesis of RA.
【Fund】: 杭州市医药卫生科技研究基金资助项目(01A013)
【CateGory Index】: R593.22
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