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《Journal of Radioimmunology》 2005-06
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Clinical Significance of Dynamic Determinations of Plasma Adrenomedullin Levels in Full-term Neonates with Hypoxid-Ischemic Encephalopathy

Zhang Shifa,Zhou Mingxiong,Zhang Xinlu,et al.Department of Pediatric,Yijishan Hospital,Wannan Medical College,WuHu(241001)  
Objective To study the dynamic changes of plasma adrenomedullin(ADM) levels in full-term neonates with Hypoxic-ischemic encephalopathy(HIE).Methods Plasma ADM levels were measured with RIA in 32 full-term neonates with HIE on 1st,3rd and 7th day after parturition,and in 30 controls.Results Plasma levels of ADM in neonates with HIE on 24h,3d and 7d were 139.58±37.86pg/ml,121.97±35.73pg/ml and 97.25±21.27pg/ml respectively,differences between each other were all significant(P0.05).The values at 24h and on d3 were significantly higher than those in controls(87.49±15.00pg/ml,P0.05),while those on d7 were not(vs control,P0.05).Conclusion The increase of plasma ADH levels after the incident of HIE was probably an auto-protective regulatory process against the adverse effect of increase of ET,TNF-α and other cytokines.
【CateGory Index】: R722.1
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