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《Journal of Radioimmunology》 2005-06
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Clinical Significance of Dynamic Determinations of Plasma Adrenomedullin Levels in Full-term Neonates with Hypoxid-Ischemic Encephalopathy

Zhang Shifa,Zhou Mingxiong,Zhang Xinlu,et al.Department of Pediatric,Yijishan Hospital,Wannan Medical College,WuHu(241001)  
Objective To study the dynamic changes of plasma adrenomedullin(ADM) levels in full-term neonates with Hypoxic-ischemic encephalopathy(HIE).Methods Plasma ADM levels were measured with RIA in 32 full-term neonates with HIE on 1st,3rd and 7th day after parturition,and in 30 controls.Results Plasma levels of ADM in neonates with HIE on 24h,3d and 7d were 139.58±37.86pg/ml,121.97±35.73pg/ml and 97.25±21.27pg/ml respectively,differences between each other were all significant(P0.05).The values at 24h and on d3 were significantly higher than those in controls(87.49±15.00pg/ml,P0.05),while those on d7 were not(vs control,P0.05).Conclusion The increase of plasma ADH levels after the incident of HIE was probably an auto-protective regulatory process against the adverse effect of increase of ET,TNF-α and other cytokines.
【CateGory Index】: R722.1
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Chinese Journal Full-text Database 5 Hits
1 Zhang Shifa,Zhou Mingxiong,Zhang XinluDepartment of Pediatric,Yijishan Hospital,Wannan Medical College,WuHu(241001);Outcome Prediction Value of Determination of Cord Blood ADM Concentrations in Neonates with Perinatal Asphyxia Events[J];Journal of Radioimmunology;2006-05
2 Gong ZengDepartment of Medical Laboratory,XiSan People's Hospital,WuXi,Jiangsu(214011)Ma Yunbao,Zhang XiaoyiDepartment of Nucleal Medicine,Changshu No.2 Hospital,Medical College of Yangzhou University,Jiangsu(215500);Clinical Significance of Determination of the Changes of Serum Levels of SOD,IGF-Ⅱ,TNF-α and Several Cytokins in Children with Bronchial Pneumonia[J];Journal of Radioimmunology;2006-06
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【Secondary References】
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1 YANG Mei1,LIN Li-xing1,WANG Jie2,ZHANG Zhi-ling1,YUAN Er-wei1(1.Department of Pediatrics,the First Hospital of Lanzhou University;2.Department of Pediatrics,Maternal and Child Health Hospital of Lanzhou,Lanzhou 730000,Gansu Province,China);Changes of Humoral Immunity in Newborn Infants with Hypoxic-Ischemic Encephalopathy and Its Correlative Factors[J];Journal of Applied Clinical Pediatrics;2009-02
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3 GUO Yan1a,LI Hong-ying1b,CHEN Xiao-qing2,ZHOU Xiao-yu1a(1a.Department of Neonatology;1b.Department of Rehabilitation,Nanjing Children's Hospital Affiliated to Nanjing Medical University,Nanjing 210008,Jiangsu Province,China;2.Department of Pediatrics,Jiangsu Province Maternity and Child Care Center,Nanjing 210036,Jiangsu Province,China);Effects of Antenatal Dexamethasone and Betamethasone Application in Pregnant Rats on Development of Brain in Offspring Premature Rats[J];Journal of Applied Clinical Pediatrics;2009-14
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