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《Radiologic Practice》 2010-08
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Preliminary study of computational stability about quantitative DCE-MRI in breast neoplasm

MAO Jian,LI Rui-ming,GU Ya-jia,et al.Department of Radiology,the Affiliated Cancer Hospital of Fudan University,Shanghai 200032,P.R.China  
Objective:To discuss the impact about calculating accuracy of volume transfer constant (Ktrans)in different scan schedules of quantitating breast dynamic contrast enhanced magnetic resonance imaging.Methods:41 patients with breast neoplasms were divided to two groups (A、B) according to examining time.In group A (16 patients) vein remaining needle was inserted and connected to high pressure injector after T1map scan sequence,then automatic prescanning was carried out to determine central frequency of T1 dynamic contrast enhanced scan and dynamic contrast enhanced scan sequence was performed while contrast media was injected.In group B (25 cases ) vein remaining needle was inserted and connected to high pressure injector before T1map scan sequence,automatic prescanning was skipped after T1map scan sequence,then dynamic contrast enhanced scan sequence was carried out and contrast media was injected after first phase scan.Images transferred to GE ADW4.3 workstation and used cine software to calculate Ktrans of neoplasms.In the end,evaluate matching degrees of Ktrans of neoplasms with pathologic result using different scan schedules.Results:T1 maps of group A (16 cases) were obvious mismatch with T1 perfusion maps and Ktrans value of 1 case was compatible with pathologic result,incompatible in 15 cases.T1 maps of group B (25 cases) were match well with T1 perfusion maps and Ktrans value of 24 cases were compatible with pathologic result,incompatible in 1 case.A significant difference was found between those two groups (χ2=29.556,P0.01).Conclusion:Correct planning of scan program and suitable using of parameter in scanning sequence were important for acquiring of accurate angiogenesis parameters.Time selecting of intravenous injection and controlling of central frequency influenced accuracy of Ktrans value directly.
【CateGory Index】: R445.2
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