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《Chinese Journal of Forensic Medicine》 2005-01
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Animal model of graded impact brain injury in rats

( WU Xu, WANG Bao-jie, ZHANG Guo-hua, et al. Department of Forensic Pathology, Faculty of Forensic Medicine, China Medical University, Shen yang 110001,China)  
Objective To produce a new animal model of brain injury by graded impact. Methods The model of graded impact brain injury in rats was set up by utilizing a new weight-drop device designed. Pathological changes were observed in 78 rats. Results With the increased extent of trauma, brain contusion became evident. In mild injury group, pathological lesions were detected in superficial layer of cerebral cortex under impact area. In moderate injury group, pathological lesions of basal nuclei, hippocampus, corpus callosum and thalamus in deep cerebral cortex were observed. In severe injury group, pathological lesions deepened to brainstem with more extensive supratentorial brain lesion. Conclusion The results indicated that the mechanism of the cerebral contusion in the model was similar to that of accelerating brain injury in practice, and the animal model created will be useful for further study on the pathophysiological mechanism following traumatic brain injury to of various degree.
【Fund】: 辽宁省鞍山市科技三项基金(2004-373)
【CateGory Index】: D919
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