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《Chinese Journal of Forensic Medicine》 2009-03
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Analysis of herbicide paraquat in urine and blood by gas chromatography coupling tandem mass spectrometry

ZHANG Ting,TAN Jiayi,QI Baokun,ZHU Yu,JIANG Zhoalin/China Criminal Police University,Shenyang 110035,China  
Objective A new method was developed to the analysis of paraquat in urine and blood by sold-phase extraction(SPE) using exchange resin and gas chromatography coupling tandem mass spectrometry (GC/MS/MS).Methods Urine samples were sticked with ethyl paraquat(internal standard,IS),extracted by SPE using 732 cation exchange resin.The blood samples were deproteined with trifluoroacetic acid and then were extracted by SPE using 732 cation exchange resin.The extracts were reducted under alkaline conditions in aqueous matrix with sodium borohydride.The reduction products were extracted with organic solvent and analysed by gas chromatography coupling tandem mass spectrometry.Results The extraction efficiency of paraquat in urine and blood were 76%and 74%,respectively.The limits of detection(LOD) of paraquat in urine and blood were 2ng/mL and 10ng/m,spectively.The sticked recoveries of the blank urine were 99.6±5.6%(mean±CV) at 100ng/mL and the sticked recoveries of the blank blood were 99.3±7.6%(mean±CV) at 500ng/mL,respectively. Conclusion This method is sensitative enough to apply in the analysis of criminal and clinical toxicology.
【CateGory Index】: D919
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