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《Chinese Journal of Forensic Medicine》 2009-03
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Analysis of herbicide paraquat in urine and blood by gas chromatography coupling tandem mass spectrometry

ZHANG Ting,TAN Jiayi,QI Baokun,ZHU Yu,JIANG Zhoalin/China Criminal Police University,Shenyang 110035,China  
Objective A new method was developed to the analysis of paraquat in urine and blood by sold-phase extraction(SPE) using exchange resin and gas chromatography coupling tandem mass spectrometry (GC/MS/MS).Methods Urine samples were sticked with ethyl paraquat(internal standard,IS),extracted by SPE using 732 cation exchange resin.The blood samples were deproteined with trifluoroacetic acid and then were extracted by SPE using 732 cation exchange resin.The extracts were reducted under alkaline conditions in aqueous matrix with sodium borohydride.The reduction products were extracted with organic solvent and analysed by gas chromatography coupling tandem mass spectrometry.Results The extraction efficiency of paraquat in urine and blood were 76%and 74%,respectively.The limits of detection(LOD) of paraquat in urine and blood were 2ng/mL and 10ng/m,spectively.The sticked recoveries of the blank urine were 99.6±5.6%(mean±CV) at 100ng/mL and the sticked recoveries of the blank blood were 99.3±7.6%(mean±CV) at 500ng/mL,respectively. Conclusion This method is sensitative enough to apply in the analysis of criminal and clinical toxicology.
【CateGory Index】: D919
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Zhao-hong,WANG Zhong,LIU Xue-jun,et al.Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China;Detection of paraquat in biological tissues by LC/MS/MS[J];Chinese Journal of Forensic Medicine;2008-02
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 Zeng Ming,Ouyang Xian,Chen Mao-Kun,Hao Yu(Huadu Entyr-exit Inspection and Quarantine Bureau,Guangzhou 510800);Determination of Paraquat by Resonance Rayleigh Scattering Method[J];Chinese Journal of Analytical Chemistry;2008-01
2 HUANG Lu-yao1, LIAO Lin-chuan1, CHEN Li-li1, SU Gui2, LI Wen-jia2, HE Rong1, YAN You-yi1, YANG Lin1 (1. West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China; 2. West China School of Pharmacy, Sichuan University, Chengdu 610041, China);Analysis of Paraquat in Blood and Urine by Sodium Borohydride/Nickel Chloride Chemical Reduction-Gas Chromatography/Thermionic Specific Detector[J];Journal of Forensic Medicine;2008-06
3 Fei Dong1,2,Chen Meilan2.(1.Department of Material and Chemical Engineering,Guilin University of Technology,Guilin Guangxi 541004;2.College of Biology and Environment,Shuren University,Hangzhou Zhejiang 310015);Determination of paraquat in vegetable by ion chromoatography with UV detection[J];Environmental Pollution & Control;2008-06
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6 YANG Yu-ping1,LI Sheng-ying1,ZHAO Ying2,et al(1.Department of Pharmacology,Xinxiang Medical College,Xinxiang 453003,China;2 Department of Clinical Pharmacology,Xinxiang Medical College,Xinxiang 453003,China);High performance liquid chromatography method for the determination of paraquat in human plasma[J];Journal of Xinxiang Medical College;2008-05
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 (WANG Zhao-hong,WANG Zhi-ping,He Yi,et al./Forensic Science Institute of Public Security Ministry,Beijing 100038,China);Detection of Paraquat in Biological Fluid by HPLC[J];Chinese Journal of Forensic Medicine;2007-06
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