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《Chinese Journal of Forensic Medicine》 2011-03
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Study on the retention behavior of barbitals in micellar liquid chromatography

JIANG Wenhui1,CHENG Xiangwei2,CHU Jianxin3/1.The People's Procuratorate of Hangzhou,Hangzhou 310014,China;2.Zhejiang Police College,Hangzhou 310053,China;3.The People's Procuratorate of Zhejiang Province,Hangzhou 310012,China  
Objective The retention characteristics of barbitals in micellar liquid chromatography(MLC) was investigated.Methods Using sodium dodecyl sulfate(SDS) as mobile phase,the effect of SDS micelle concentrations,pH,organic modifiers concentrations,and column temperature on the retention behavior of barbitals was investigated.Results The experimental results showed: with increasing SDS micelle concentrations,organic modifiers concentrations and column temperature,the capacity factor(k′) of barbitals decreases.Conclusion There is a good linear relationship between the capacity factor(k′) and SDS micelle concentrations,organic modifier concentrations,and column temperature.There is a nonlinear relationship between the retention time of barbitals(tR) and the pH value of mobile phase.
【CateGory Index】: D919
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Mao Jingjing, Sun Jin, Li Jie, Gao Kun, He Zhonggui~* (Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016);The Retention Behavior of Solutes in Anionic Micellar Liquid Chromatography[J];Chinese Journal of Analytical Chemistry;2005-09
2 YE Li-ming, MA Tao, CHEN Cong , CHEN Yu( West China School of Pharmacy, Sichuan University, Chengdu 610041, China ; West China Hospital, Sichuan University, Chengdu 610041, China);Study on predictive quantitative retention-activity relationship models of non-steroidal anti-inflammatory drugs by micellar liquid chromatography[J];Chinese Pharmaceutical Journal;2005-22
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Sun Jin Wang Yongjun He Zhonggui~(*)(Department of Biopharmaceutics,School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China);Biopartitioning Chromatography: High Throughput Screening in Drug Membrane Permeability and Activity[J];Progress in Chemistry;2006-Z2
2 JIA,Hong-Ying~a YANG,Geng-Liang~(*,a,b) XIN,Pei-Yong~a CHEN,Yi~a (~a Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080)(~b College of Pharmacy,Hebei University,Baoding 071002);Prediction of Octanol-Water Partition Coefficients (log P) of Drugs by Micellar Liquid Chromatography Simulating Biomembrane[J];Acta Chimica Sinica;2007-08
3 Du Xihua and Feng Changjun ( Department of Chemistry, Xuzhou Education College, Xuzhou, 221006, Jiangsu, China, Department of Chemistry,Xuzhou Normal University, Xuzhou, 221116, Jiangsu, China);The QSAR research of the TIBO derivative and topological integration index[J];Computers and Applied Chemistry;2007-12
4 SHI Jie-hua,Lü Yuan-yuan,XIAO Ke-ke,DAI Jie,ZHU Bei(College of Pharmaceutics,Zhejiang University of Industry,Hangzhou 310032,China);Micellar LC Determination of Ibuprofen in Its Preparation and Urine Sample[J];Physical Testing and Chemical Analysis(Part B:Chemical Analysis);2010-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 SUN Jin *, CHENG Gang, HE Zhong gui, WANG Shu jun (Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China);Evaluation of interaction between drugs and ordered phospholipid membrane by immobilized artificial membrane chromatography[J];Acta Pharmaceutica Sinica;2003-09
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