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《Chinese Journal of Forensic Medicine》 2011-03
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Study on the retention behavior of barbitals in micellar liquid chromatography

JIANG Wenhui1,CHENG Xiangwei2,CHU Jianxin3/1.The People's Procuratorate of Hangzhou,Hangzhou 310014,China;2.Zhejiang Police College,Hangzhou 310053,China;3.The People's Procuratorate of Zhejiang Province,Hangzhou 310012,China  
Objective The retention characteristics of barbitals in micellar liquid chromatography(MLC) was investigated.Methods Using sodium dodecyl sulfate(SDS) as mobile phase,the effect of SDS micelle concentrations,pH,organic modifiers concentrations,and column temperature on the retention behavior of barbitals was investigated.Results The experimental results showed: with increasing SDS micelle concentrations,organic modifiers concentrations and column temperature,the capacity factor(k′) of barbitals decreases.Conclusion There is a good linear relationship between the capacity factor(k′) and SDS micelle concentrations,organic modifier concentrations,and column temperature.There is a nonlinear relationship between the retention time of barbitals(tR) and the pH value of mobile phase.
【CateGory Index】: D919
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