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《Acta Materiae Compositae Sinica》 2007-06
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Syntheses and cell compatibilities of CPP/CS composite for bone repair

ZHANG Zhibin1,2,LI Daguang2,SU Zhiqing2,WAN Changxiu2(1.College of Bioengineering,Southwest Jiaotong University,Chengdu 610031,China;2.College of Polymer Science and Engineering,Sichuan University,Chengdu 610065,China)  
A series of macroporous calcium polyphosphate/chitosan(CPP/CS) composite rod and microporous CPP/CS composite particle were synthesized with CPP and CS using two technologies by a heat-dispersion suspension complex method.The structure and morphology of the composites were measured by IR spectrum and SEM.The hydrogen bond was formed between —NH2 of CS and —PO of CPP in the composites.The aperture of the macroporous composite is about 50~300 μm,the porocity is 71.13%,which was determined by the ethanol infiltration method.And for the microporous composites,the aperture and porocity are 10~100 μm and 40.76%,respectively.The former is suitable for the need of bone tissue engineering scaffold material,but the later is not suitable.The cell compatibility of macroporous composite was better than that of microporous composite.The cell compatibility is the best when CPP/CS=7/3.The compression strength of CPP is increased by the complex method.And the compression strength of composite is also the highest when CPP/CS=7/3.
【Fund】: 国家自然科学基金资助项目(50472091;50573061)
【CateGory Index】: R318.08
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