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《Analysis and Testing Technology and Instruments》 2011-01
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Determination of Dissociation Constant and Binding Constant of Famciclovir

CHEN Yi-ting,SU Bi-ling,HUANG Lu,LIN Qi (Chemistry and Chemical Engineering Department of Minjiang University,Fuzhou 350108,China)  
Both the dissociation constants of famciclovir obtained were 3.8 using ultraviolet spectrophotometry with the wavelengths at 225 nm and 305 nm.Bovine serum albumin was added to a Na2HPO4-KH2PO4 buffer solution(pH 7.0) with famciclovir.The binding constant was measurd by the double-reciprocal analysis.The results showed that bovine serum albumin and famciclovir formed a 1∶4 complex,and the binding constant obtained was 4.51×106 L/mol.This method is simple and reliable.
【Fund】: 福建省青年人才创新项目(2008F3081 2010J05029);; 福建省教育厅科技项目(JA10222 JB09188);; 食品安全分析与检测教育部重点实验室(福州大学)开放课题(FS10002 FS10005);; 福建省高校杰出青年科研人才培育计划资助
【CateGory Index】: R96
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