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《Chinese Journal of Analytical Chemistry》 1989-07
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PARTIAL LEAST-SQUARES REGRESSION APPLIED TO PHARMACEUTICAL ANALYSIS

Xie Yulong (Department of Chemistry,Xiangtan University) Liang Yizeng Yu Ruqin (Department of Chemistry & Chemical Engineering,Hun an University)  
In this paper, the application of partial least-squares regression (PLS) method to multicomponent drug analysis using UV spectrophotometry has been investigated. The PLS method is comparable favourably with ordinary least squares (OLS) and multiple linear regression (MLR) methods especially when there is interaction between the components to be determined and the spectral additivity is violated. The procedure was applied to the assay of aminopyrine-phenacetin composite tablets and satisfactory recoveries were obtained.
【Fund】: 国家自然科学基金
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