Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Analytieal Chemistry》 1998-11
Add to Favorite Get Latest Update

Adsorptive Behavior and Determination of Ketoconazole at Glassy Carbon Electrodes

Cheng Qiong, Peng Tuzhi, Hu Xiaobo, Yang Liju (Department of Chemistry, Hangzhou University, Hangzhou 310028)  
A sensitive stripping voltammetry to determine the antifugal drug-ketoconazole was reported. Ketoconazole was preconcentrated on the glassy carbon electrode in an open circuit, stripped by differential pulse voltammetry in a blank solution. There was a linear relationship between the stripping current and the concentration of ketoconazole in the range of 2× 10-10-1× 10-5 mol/L. The detection limit calculated by three times signal to noise was 4 × 10-11 mol/L. The calibration curves of ketoconazole in urine and serum samples were established by this method. The adsorptive behavior of ketoconazole at the glassy carbon electrode was investigated by chronocoulometry. The adsorption corresponded to the Frumkin type isotherm, and the free energy of adsorption was calculated to be 3. 59 x 104 J/mol at 25℃. Bulk electrolysis method was used to measure the number of transferred electrons in the oxidative reaction, and the mechanism of electrode was suggested.
【Fund】: 浙江省自然科学基金;; 浙江省测试基金
【CateGory Index】: O657.1
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved