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《CHINESE JOURNAL OF ANALYTIEAL CHEMISTRY》 2000-06
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Recognition and Determination of Ofloxacin Enantiomers by Synchronization-Derivative Fluorimetry

Gong Qiaojuan; Jin Weijun; Dong Chuan (Department of Chemistry,Shanxi university,Taiyuan 030006) (Yuncheng Advanced Training College ,Yuncheng 044000)  
The fluorescence properties of beth of ofloxacin and the internal hormones in human urine were investigated in detail.The experimental results indicate that synchronization lst derivative fluorimetry can be appled to the determination of trace ofloxacin without separation. R and S enantiomer of ofloxacin were distinguished at pH 3. A new recognition and determination method of enantiomers of ofloxain using the synchronous-first order derivative fluorimetry has been developed.The linear range is 0.36×10-6 g/mL~31 .6×10-6 g/mL (R), 0.36×10-6 g/mL~2.89×10-6 g/mL (S) and 3.16× 10-6 g/mL~ 31 .6×10-6 g/mL (S), detection limit is 0.36×10-6 g/mL (both R and S). RSD is less than 5.0% and the recovery is within the range of 97% ~ 104%.
【Fund】: 国家自然科学基金!29875016;;山西省自然科学基金!991010;;山西省教委资助!99001
【CateGory Index】: O657.3
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