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《CHINESE JOURNAL OF ANALYTIEAL CHEMISTRY》 2000-10
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A Study on the Binding Characteristics of Molecular Imprinted Polymer Selective for Cefalexin in Aqueous Media

Guo Hongsheng, He Xiwen (Department of Chemistry, Nankai University, Tianjin 300071)  
A kind of molecular imprinted polymer was prepared using cefalexin as the template molecule, both 2-(trifluoromethyl) acrylic acid and 4-vinylpyridine as functional monomer.The bulk polymer was ground up sieved and investigated in equilibrium binding experiment to evaluate the binding characteristic of the cefalexin-imprinted polymer. Scatchard analysis showed that two classes of binding sites were formed in the imprinted polymer under the studied concentration. The polymer gave much higher binding capacity for cefalexin than the non-imprinted polymer with the same chemical composition. The selectivity was evaluated by distribution coefficients of cefalexin and other compounds with similar structure. The results showed that the imprinted polymer exhibited high affinity for cefalexin among the tested compounds.
【Fund】: 国家自然科学基金!(No.29775011);; 天津市自然科学基金!(No.003602211)资助课题
【CateGory Index】: O631
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