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《Chinese Journal of Analytieal Chemistry》 2001-10
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Prediction of Intestinal Absorption of Drugs with Mimetic Biomembrane Chromatography

Mao Xiqin, Zou Hanfa, Luo Quanzhou, Kong Liang, Li Xin, Sun Naichang (National Chromatographic Research & Analysis Center Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011)  
Silica coated lecithin was used as solid phase, the amount of lecithin coated and mechanical strength of the packing were all superior to gel, the traditional matenal used in the process of immobilization of liposome, and the stability of lecithin coated on silica was also good. The retention values of six drugs on mimetic biomembrane chromatography have been measured with three different pH buffers (pH 5.4, pH 7.0 and pH 7. 4) as mobile phase. The weighed retention values have been proposed to simulate the intestinal absorption of drugs. It was observed that the linear con-elation coefficient (r = 0.9365) was higher than that with single buffer as mobile phase. Comparing the result above with that of correlation between retention of drugs on C18 reversed phase chromatographic column and distributive coefficient of drugs in octanol-water system and intestinal absorption, it was observed that mimetic biomembrane chromatography had better precision than other two models when they were used to predict intestinal absorption of drugs.
【CateGory Index】: O657.7
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【References】
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1 LIU Ya-ping ZHANG Guan-yong(Department of Chemistry ECUST. Shanghai 200237);Extraction of Tyrosine with AOT Reversed Micelle[J];Amino Acids & Biotic Resources;2001-02
2 HuangZaohua;Hong Xiaokun(Shanghai University of Traditional Chinese Medicine 200032);The Application of TLC-SRS to the Analysis of Anthraquinone Aglycons and Glycosides in Rhubarb[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;1998-06
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