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《Chinese Journal of Analytical Chemistry》 2004-11
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Progress in Nuclear Magnetic Resonance Study on the Interaction between Drug Ligand and Macromolecular Receptor

Ji Zhusheng 1,2 , Liu Maili 2, Hu Jiming *1 1(The Center of Analysis and Measurement, Wuhan University, Wuhan 430072) 2(State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071)  
The interaction between drug and target macromolecule in vivo is one of the most important factors that determine the therapeutic activity and metabolic stability of the drug. How to rapidly and efficiently discover drug that can interact with target molecular and inhibit its in vitro activity has become an issue of major concern in pharmaceutical industries. Nuclear magnetic resonance (NMR) is now a very important approach to study the interaction between small ligand and biomolecule. Both ligand and receptor experience changes in the interaction process. Drug screening by NMR can be achieved by monitoring signals from ligand . The recent developments in this field are reviewed.
【Fund】: 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室资助课题 (No .9915 0 8)
【CateGory Index】: O657.2
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