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《Chinese Journal of Analytical Chemistry》 2005-06
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Determination of Epirubicin and Its Impurities in Pharmaceutical by Hydrophilic Interaction Chromatography

Li Ruiping, Dong Lili, Huang Junxiong (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085)  
A novel method for the determination of epirubicin by hydrophilic interaction chromatography (HILIC) using high purity silica column with highly polar organic-aqueous buffer as mobile phase has been developed. The buffer pH and concentration in the mobile phase as well as the flow rate have been optimized. The optimal mobile phase is 90% (V/V) acetonitrile in 40 mmol/L formate buffer (pH 2.9). The flow rate was 1.0 mL/min. The system suitability has been tested under the optimal chromatographic condition, and the results show that the resolutions between the adjacent components and the asymmetry factors of the solutes meet the pharmacopoeia requirements. The proposed method has good linearity (r=0.9971~0.9991) and reproducibility (RSD1.0% for the peak area). It has been proved simple and convenient, and applied in the determination of epirubicin and its impurities in epirubicin raw product with satisfactory results.
【CateGory Index】: O657.7
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Ying, SHENG Long - sheng, ZHANG Zheng - xing and AN Deng - kui(Analysis Center, China Pharmaceutical University, Nanjing 210009);Determination of Related Substances in Epirubicin by Using LC/ESI/MS[J];Chinese Journal of Pharmaceutical Analysis;2001-06
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Wang Li, Xiao Hongbin, Hu Jiehan, Wang Jianing, Liang Xinmiao * (Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116012);Study of p-Hydroxyphenylic Compounds in Gastrodia Elata Blume by High Performance Liquid Chromatography-Electrospray -Mass Spectrometry[J];Chinese Journal of Analytical Chemistry;2003-08
2 ZhANG Jing-xia, TANG Ke-hui*, Chang Ning, XU Ming-qin, ZHANG Chun-ran, WANG Yu-chi (Department of Quality Control Studies, Sichuan Industrial Institute of Antibiotics, China National Pharmaceutical Group Corporation, Chengdu 610052, China);Development and Application of Chemiluminescence Method in Antibiotic Analysis[J];World Notes on Antibiotics;2009-02
3 GONG Xiao-li,QIN Yong-ping,LIANG Mao-zhi,YU Qin,NAN Feng(Department of Clinical Pharmacology,West China Hospital,Sichuan University,Chengdu 610041,China);Determination of Epirubicin in rat plasma and tissue by HPLC with fluor-detection and MS/MS-detection[J];West China Journal of Pharmaceutical Sciences;2008-01
4 ZHANG Ya-ni,WANG Kai-mei,ZHANG Zhi-gang,JIANG Ai-bin,WAN Zhong-yi,YANG Zi-wen (The Branch Center of Bio-pesticide,Hubei Agricultural Scientific and Technological Innovation Center,Hubei Bio-pesticide Engineering Research Center,Wuhan 430064,China);Separation and Purification of Bioactive Metabolites Produced by Actinomycetes WS-13182[J];Hunan Agricultural Sciences;2009-11
5 RAO Tong-de (Dept of Chemistry,Chongqing Three Geogres College, Wanzhou, Chongqing404000 );A Study for the Determination of Antibiotics by Chemiluminescence[J];Journal of Chongqing Three-gorges University;2005-03
6 ZHANG Chengxiao QI Honglan (School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062);Progress in Electrogenerated Chemiluminescence Analysis[J];World Sci-tech R & D;2004-04
7 LIU Hua-jun, ZENG Hao, LI Shu-qin, WANG Gao-fang (Department of Chemistry and Chemical Engineering, Xiangfan University, Xiangfan 441053, China);A Study of Determination of Iodine by Electrochemistry[J];Journal of Xiangfan University;2002-05
8 Ye Fang1, Hu Hai-rong1, Tan Shao-yun1, Yang Fang1 and Yao Jun-hua2 (1 Guangzhou Bai Yun Shan Pharmaceutical Factory, Guangzhou 510515; 2 Sun Yat Sen University, Guangzhou 510080);Determination of degradation products in cephathiamidin by using LC-MS[J];Chinese Journal of Antibiotics;2005-12
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Cheng Hongyan; Li Suwen; Li Yanping; Zhang Hongqing; Xue Shaobai (Department of Biology, Beijing Normal University, 100875, Beijing, China);ANALYSIS OF FLUORESCENCE EMISSION SPECTRA OF THE ANTICANCER DRUG DOXORUBICIN[J];JOURNAL OF BEIJING NORMAL UNIVERSITY(NATURAL SCIENCE);1999-02
2 Hu Jingbo Li Qilong (Department of Chemistry, Beijing Normal University, 100875, Beijing, China);STUDIES ON THE ELECTROCHEMICAL OF MITOXANTRONE AT THE Co/GC MODIFIED ELECTRODE AND ITS APPLICATION[J];Journal of Beijing Normal University(Natural Science);2003-02
3 YANG Pei-hui~1,CHEN Xiao-xiang~1,CAI Ji-ye~1,ZENG Hui-lan~2(1.Department of Chemistry of Jinan University,Guangzhou 510630,China;2.The First Accessorial Hospital of Medicine College of Jinan University,Guangzhou 510630,China);Interaction between Transferrin and Adriamycin[J];Chinese Journal of Luminescence;2005-05
4 Yang Zhijie (Department of Chemistry, Dali Teacher's College, Dali 671000)Liu Shenghui; Ye Jiannong; Fang Yuzhi(department of Chemistry, East China Normal University, Shanghai 200062);Voltammetric Determination of Doxorubicin Hydrochloride With Wax-Impregnated Graphite Electrode[J];Chinese Journal of Analytieal Chemistry;1996-04
5 Tan Xuecai; Li Qilong; Shang Jun (Department of Chemistry, Beijing Normal University, Beijing 100875);Single-sweep Oscillopolarography of Adriamycin[J];Chinese Journal of Analytieal Chemistry;1996-07
6 Hu Jingbo, Zhi Yao, Li Qilong (Department of Chemistry, Beijing Normal University, Beijing 100875);Electrochemical Behaviour of Adriamydn and Its Application at Co/GC Ion Implantation Modified Electrode[J];Chinese Journal of Analytical Chemistry;1999-11
7 Liu Yongming *, Li Guizhi, Sun Xifen (College of Chemistry, Yantai University, Yantai 264005);Study on the Interaction between Colchicine and Bovine Serum Albumins by Fluorescence Method[J];Chinese Journal of Analytical Chemistry;2004-05
8 LUO Ji wen 2, ZHANG Min 1, ZHANG Rong ying 1, PANG Dai wen 1* (1. Department of Chemistry, Wuhan University, Wuhan, 430072; 2. Department of Chemistry, Yulin Normal College, Yulin, 537000, P. R. China);Electrochemical Behavior of Daunomycin at DNA-Modified Graphite Powder Microelectrodes and Related Analytical Application[J];Journal of Analytical Science;2002-01
9 SUN Yan-yi~(1,2), WU Kang-bing~(1),HU Sheng-shui~(1*) (1. Department of Chemistry, Wuhan University, Wuhan 430072; 2. Technology College of Xiangfan, Xiangfan, Hubei 441021);Studies on the Electrochemical Behaviors and Analysis of Adriamycin at a MWNT Film Electrode[J];Journal of Analytical Science;2004-01
10 Tan Xuecai,Hu Jingbo,Gang Lanxin and Li Qilong (Department of Chemistry,Beijing Normal University ,Beijing 100875);Study on Adsorptive Voltammetry of Adriamycin (ADM)[J];ANALYTICAL LABORATORY;1997-01
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 An Jingru, Lin Jianguo (Department of Chemistry, Fuzhou University, Fuzhou 350002);Properties, of Electrochemiluminescence of a New Reagent 6-(2, 4-Dihydroxyphenylazo)-2, 3-dihydro-1, 4-phthalazine-1, 4-dione[J];Chinese Journal of Analytical Chemistry;1992-06
2 Yao Qing An Jing-ru(Teaching and Kesearch Group of Chemistry, (Department of Chemistry, Fuzhou University) Fujian Medical College, Fuzhou, 350004);The Determination of Luminescence-Labelled Agent ABEI by Electrogenerated Chemiluminescence[J];Chemical Research In Chinese Universities;1991-04
3 WANG Hong-Fei; YANG Pin; LI Qing-Shan; WU Qiang(Department of Chemistry, Nanjing University; State Key Lab. of Coordination Chemistry,Nanjing, 210093; Institute of Molecular Science, Shanxi University, Taiyuan, 030006);Electrochemistry Characteristics of Adriamycin-Fe(Ⅲ) Complex and Its Interaction with DNA[J];CHEMICAL RESEARCH IN CHINESE UNIVERSITIES;1997-05
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