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《Chinese Journal of Analytical Chemistry》 2012-05
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Determination of Fluoroquinolones in Grass Carp by High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Using Mixed-templates Imprinted Polymer Extraction

LIU Peng-Yan*,SHEN Jie,LIU Lei (College of Chemistry and Environmental Sciences,Heibei University,Baoding 071002,China)  
The molecularly imprinted polymer(MIP) has been prepared using levofloxacin and ciprofloxacin as the mixed-templates,α-methacrylic acid(MAA) as functional monomers and trimethylolpropane trimethylacrylate(TRIM) as crosslinker.A method has been established for simultaneous determination of residues of ten fluoroquinolones in grass carp by high performance liquid chromatography-ion trap mass spectrometry(HPLC-ITMS) combining with molecularly imprinted polymer solid phase extraction(MISPE).The samples were extracted with 2% acetic acid in acetonitrile and defatted with n-hexane,then purified by the self-made molecularly imprinted cartridge.The preparation of samples and the separation conditions had been optimized,HPLC was performed with a gradient elution program while acetonitrile and water(containing 0.05% formic acid) were used as mobile phase.The identification and quantification were done with ion trap mass spectrometry.The recove-ries ranged from 80.6% to 104.6% with a relative standard deviations of 8.6%.The limits of detection(LOD) were 0.11-0.25 μg/kg and the limits of quantification(LOQ) were 0.35-0.84 μg/kg.This method is suitable for validation and multi-residue analysis of fluoroquolones in aquatic products.
【Fund】: 河北省自然科学基金(No.B2005000105);; 河北省科技支撑计划(No.12220402D)资助项目
【CateGory Index】: TS254.7;O657.63
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Chinese Journal Full-text Database 3 Hits
1 FEI Jianzhong,HE Rongjun,ZHU Fangming,SUN Peilong(College of Biology and Environmental Engineering,Zhejiang University of Technology, Hangzhou 310014,Zhejiang,China);Progress of molecular imprinted polymer of fluoroquinolones and its application on the food determination[J];Chemical Industry and Engineering Progress;2010-S2
2 Jiao Hao-yan1,Xu Feng-guo2,Tian Yuan2 and Zhang Zun-jian2(1 Guangdong Food and Drug Vocational College,Guangzhou 510520;2 Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 210009);Study on fluoroquinolones by triple quadrupole mass spectrometer[J];Chinese Journal of Antibiotics;2009-06
3 MA Bin~1,SUN Yu-ming~1,CHEN Xiao-yan~2,ZHONG Da-fang~(2,*)(1.Laboratory of Drug Metabolism and Pharmacokinetics,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China);Analysis of Fluroquinolones by Electrospray Ion Trap Mass Spectrometry[J];Journal of Chinese Mass Spectrometry Society;2006-03
Chinese Journal Full-text Database 10 Hits
1 YANG Fang1,3,PANG Guo-fang2,LIU Zheng-cai1,LU Sheng-yu1,LIN Yong-hui1,YU Kong-jie1,LI Yao-ping1 and CHEN Guo-nan3(1.Fujian Entry-exit Inspection and Quarantine Bureau,Fuzhou 350001;2.Qing Huangdao Entry-exit Inspection and Quarantine Bureau,Qing Huangdao 066002;3.Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety,and Department of Chemistry,Fuzhou University,Fuzhou 350002);Stimultaneous determination of 15 quinolones in aquatic products by liquid chromatography-tandem mass spectrometry[J];Chinese Journal of Analysis Laboratory;2008-12
2 Zhao Jian-hui,Tang Qing-qiang,Wu Wen-fan,Zheng Xiang-ping,Cheng Zhi-tao,Yu Chai (Fuqing Entry-exit Inspection and Quaratine Bureau,Fuqing 350300,China);Determination of Levofloxacin in aquatic products by SPE-Ultra Liquid Chromatography-Mass Spectrometry[J];Fujian Analysis & Testing;2011-05
3 ZHAO Jian-hui,WU Wen-fan,ZHENG Xiang-ping,ZHENG Yu,LIN Jing,YU Chai,Zhang Jing-hu (Fuqing Entry-Exit Inspection and Quarantine Bureau,Fuzhuu 350300,China);Simultaneous UHPLC-MS/MS Determination of Gatifloxacin,Moxifloxacin and Levofloxacin in Aquatic Products[J];Physical Testing and Chemical Analysis(Part B:Chemical Analysis);2011-06
4 Zhu Ying Zhang Hong(College of Food Science and Biotechnology Engineering,Zhejiang Gongshang University,Hangzhou 310035);Simultaneous Determination of Quinolones in Aquatic Products by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J];Journal of Chinese Institute of Food Science and Technology;2010-02
5 Jiao Hao-yan1,Xu Feng-guo2,Tian Yuan2 and Zhang Zun-jian2(1 Guangdong Food and Drug Vocational College,Guangzhou 510520;2 Center for Instrumental Analysis,China Pharmaceutical University,Nanjing 210009);Study on fluoroquinolones by triple quadrupole mass spectrometer[J];Chinese Journal of Antibiotics;2009-06
6 Xie Ying,Zhou Jing-ming,Fang Dong-sheng,Fan Jian-hui,Lin Wei and Zheng Wei(Fujian Provincial Key Laboratory of Screening for Novel Microbial Products,Fujian Institute of Microorganism,Fuzhou 350007);Structural characterization of actinomycins by electrospray ionization mass spectrometry[J];Chinese Journal of Antibiotics;2010-10
7 Chen Yu-xiang,Xie Ying,Wen Yao-ming,Zheng Jun-rong,Le Zhan-xian,Zhou Jing-ming and Zheng Wei(Fujian Institute of Microorganism,Fuzhou 350007);Study on the fragmentation pathway of tacrolimus and ascomycin by ESI MS~n under negative mode[J];Chinese Journal of Antibiotics;2011-01
8 Zhu jian1,Xie ying2,Chen Xiao-xia1,Zhou Jing-ming2,Chen Xiu-ming2,Fang Dong-sheng2 and Zheng Wei2(1 Hangzhou Huadong Medicine Group Biotechnology Institute Co.Ltd,Hangzhou 310011;2 Fujian Provincial Key Laboratory of Screening for Novel Microbial Products,Fujian Institute of Microorganism,Fuzhou 350007);Study on the fragmentation pathway of ansamycins by ESI-MS~n[J];Chinese Journal of Antibiotics;2011-02
9 Xing Yi-wen,Min Chun-yan,Miao Gang,Xu Qi(Suzhou Institute for Drug Control of Jiangsu Province,Suzhou 215002);Determination of Norfloxacin illegally added into Fuyankang Capsule by IR-UPLC-MS/MS[J];Drug Standards of China;2011-03
10 Li Lili,Luo Yi,He Songhua,Huang Lili(Guangxi Institute for Food and Drug Control,Nanning 530021,China);Simultaneous determination of 8 quinolone residues in fish meat by high performance liquid chromatography-tandem mass spectrometry[J];Chinese Journal of Food Hygiene;2012-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Guo Hongsheng,He Xiwen,Zhou Jie (Department of Chemistry,Nankai Universtity ,Tianjin 300071) Liang Hong (College of Chemistry and Life Science,Guangxi Normal University,Guilin 541004);Characteristics of Molecular Recognition of Norfloxacin Template Polymer[J];Chinese Journal of Analytieal Chemistry;2001-02
2 LU Chun-Yang+1, MA Xiang-Xia+1, HE Xi-Wen+{1*}, LI Wen-You+1, CHEN Lang-Xing+1, HE Hai-Cheng+2(1. State Key Laboratory of Functional Polymer Materials for Adsorption and Separation,Department of Chemistry, Nankai University, Tianjin 300071, China; 2. Department of Chemistry, Langfang Normal College, Langfang 065000, China);Preparation and Permeation Properties of Molecularly Imprinted Polymer Membranes with Norfloxacin as Template[J];Chemical Research In Chinese Universities;2005-07
3 HE Dan-feng1,SU Li-qiang 2,WANG Jun-tao 3(1.Department of Chemistry and Chemical Engineering,Daqing Normal University,Daqing 163712,China;2.School of Chemistry and Chemical Engineering,Qiqihar University,Qiqihar 161006,China;3.College of Arts and Science,Heilongjiang August First Land Reclamation University,Daqing 160039,China);Application study of separation of fluoroquinolone drugs imprinted polymers[J];Journal of Science of Teachers' College and University;2008-01
4 BING Nai-ci,XU Zhen-liang,WANG Xue-jun,YANG Zuo-guo(Chemical Engineering Research Center,East China University of Science and Technology,Shanghai 200237,China);Levofloxacin-Imprinted Membranes for Selective Separation of Ofloxacin under Solid Phase Extraction Conditions[J];Journal of East China University of Science and Technology(Natural Science Edition);2007-02
5 Liu Pengyan,Liu Lei,Zhang Li,Jiang Ning,Liu Zhanli,Wang Yun(College of Chemistry and Environmental Science,Hebei University,Baoding 071002);Synthesis and Characterization of Molecularly Imprinted Polymers for Recognition of Ciprofloxacin[J];Chemistry;2008-02
6 CAO Xi-min,LIAO Ling,DU Li-ming * (Center of Analysis and Test,Shanxi Normal University,Linfen 041004,China);Preparation and recognition properties of molecularly imprinted polymer for ciprofloxacin[J];Chemical Research and Application;2007-12
7 LIAN Ning,TANG Jiang-hong,LI Wei-hua,HE Xiang-hong,ZHOU Quan-fa(College of Chemistry and Chemical Engineering,Key Laboratory of Precious Metal Chemistry and Technology of Jiangsu Province,Jiangsu Teachers University of Technology, Changzhou 213001,China);Synthesis and research of molecule recognition capability of enoxacin molecularly imprinted polymer[J];Chemical Research and Application;2007-12
8 KONG Jun, HAN De-man, LIN Xiao-wen(School of Pharmaceutical and Chemical Engeering,Taizhou University,Linhai 317000 P.R.China);Synthesis and Characterization of Norfloxacin-imprinted Sol-Gel Materials[J];Science Technology and Engineering;2008-12
9 BING Nai-ci,XU Zhen-liang,YANG Zuo-guo,WANG Xue-jun(Chemical Engineering Research Center,ECUST,Shanghai 200237,China);Optimizing conditions of molecularly imprinted polymers of levofloxacin by thermal polymerization method[J];Journal of Nanjing University of Technology(Natural Science Edition);2006-01
10 SUN Hui1, DONG Xiangchao1, L Xianyu2, WANG Haibo1, HAN Jianfang1 (1. Department of Chemistry, Nankai University, Tianjin 300071, China; 2. College of Life Science, Nankai University, Tianjin 300071, China);Separation and Determination of Fluoroquinolones with a Molecularly Imprinted Polymer[J];Chinese Journal of Chromatography;2003-03
China Proceedings of conference Full-text Database 1 Hits
1 LI Ke, ZHONG Da-fang(Laboratory of Drug Metabolism and Pharmacokinetics, Shenyan Pharmaceutical University, Shenyang 110016,China);Analysis of Camptothecin and Its Derivatives by ESI-Ion Trap Mass Spectrometery[A];[C];2003
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