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《Chinese Journal of Analytical Chemistry》 2012-12
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Determination of Chlormequat in Muscles of Mice by Solid Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry

LI Chun-Mei1,2,JIN Fen*1,XU Si-Yuan1,LIU Jia-Jia1,3, JIN Mao-Jun1,SHAO Hua1,WANG Jing1,YANG Ming-Qi*2 1(Key Lab of Agro-product Quality and Safety,Institute of Quality Standards & Testing Technology for Agro-products,Chinese Academy of Agricultural Sciences,Beijing 100081,China) 2(College of Veterinary Medicine,Northwest A & F University,Yangling 712100,China) 3(COFCO Nutrition & Health Research Institute,Beijing 100083,China)  
A method for the determination of chlormequat(CQ) in muscles of mice using solid phase extraction with liquid chromatography tandem mass spectrometry was developed.CQ was extracted using acetonitrile,cleaned-up by Weak Cation-exchange(WCX) solid phase extraction(SPE) cartridges and then eluted by 3 mL of formic acid-methanol(1 ∶ 99,V/V) by gravity.The separation was performed on a hydrophilic interaction liquid chromatography(HILIC) column with aqueous solution containing 10 mmol/L ammonium acetate and 0.1% formic acid-acetonitrile(40 ∶ 60,V/V) as the mobile phase.CQ was determined in the mode of electrospray ionization source(ESI+) and multiple-reaction monitoring(MRM).The quantification was carried out by matrix-matched external standard curve.The results showed that the calibration curve was linear in the range of 5.0-500.0 μg/L with the correlation coefficient of 0.9991.The mean recovery of CQ in spiked muscle samples was 73.2%-82.3% and the relative standard deviation(RSD) was less than 9.3% at 10.0,100.0 and 200.0 μg/kg with three spiked levels(n=7).The limit of quantification(LOQ) for CQ was 10.0 μg/kg.The method was successfully applied to the analysis of trace level of CQ in muscles of mice.
【Fund】: 国家自然基金资助项目(No.21107138)
【CateGory Index】: Q593.3;O657.63
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3 ZHAO Bing-nan;HAN Yue;YIN Ren;ZHANG Shuang-ling;Chengyang NO.1 High School of Qingdao;College of Food Science and Engineering,Qingdao Agricultural University;;The Detection Method of Chlormequat Chloride in Cherry Tomato Preserves[J];食品研究与开发;2017-22
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【Co-references】
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