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Study on electrochemical behaviors and analytical application of doxorubicin hydrochloride at a glassy carbon electrode

LIU Jie,LIU Yan-mei and ZHANG Yong(School of Chemistry and Chemical Engineer,Shanxi University,Taiyuan 030006)  
In this paper,the electrochemical behavior and electrode reaction mechanism of doxorubicin hydrochloride at a glassy carbon electrode were investigated by linear sweep voltammetry and cyclic voltammetry,and experimental parameters for the determination of doxorubicin hydrochloride were optimized.The results showed that a sensitive reduction peak of doxorubicin hydrochloride was obtained in 0.01 mol/L HCl solution.The peak potential was-0.40 V(vs. SCE).The peak current was directly proportional to the doxorubicin hydrochloride concentration in the ranges of 5.0×10-8~1.0×10-6 mol/L(r=0.999) and 1.0×10-5~1.0×10-6 mol/L(r=0.998).The detection limit was 1.0×10-8 mol/L.The electrochemical behavior of doxorubicin hydrochloride on the glassy carbon electrode was investigated by cyclic voltammetry, indicating a quasi-reversible adsorptive wave.This method can be used for the determination and pharmacokinetics study of doxorubicin hydrochloride.
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