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《Chinese Journal of Analysis Laboratory》 2009-03
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Quickly Determination of ephedrine and codeine in coughsyrup by capillary electrophoresis using sweeping micellar electrokinetic chromatography technique

LI Si-guang1, LI Li-jun2, CHENG Hao2 and CAI Zhuo1 (1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004; 2. Department of Biological and Chemical Engineering, Guangxi University of Technology, Liuzhou 545006)  
Sweeping micellar electrokinetic chromatography (Sweep-MEKC) was used in determination of Ephedrine (Ep) and Codeine (Co) in CoughSyrup. Stability of this method was evaluated by intra-day, inter-day and inter-column experiment. The buffer contained 60 mM SDS, 10 mM NaH2PO4 (pH 2.20), and 18% ACN(V/V). The separation voltage was -14 kV, detected at 200 nm. Effect of pH, SDS concentration, and sample solvent was discussed. Under the optimum conditions, every determination was finished within 5 minutes. The LODs (μg/mL), linearities (μg/mL) and Rs was 0.433, 1.73~27.7, 0.9997 for Ep, and 0.833, 3.33~50.3, 0.9996 for Co, with recoveries between 96.7% and 103.5%. Peak area RSDs (%) of both Ep and Co were not more than 4.2, 8.0, 2.3 for intra-day (n=5), inter-day (n=5), inter-column (n=3) exprement respectively.
【Fund】: 广西自然科学基金(桂科自0481019)项目资助
【CateGory Index】: TQ460.72
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