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《JOURNAL OF RADIATION RESEARCH AND RADIATION PROCESSING》 1999-04
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STUDIES OF PHENOLIC CHELATING AGENTS ON FREE RADICAL SCAVENGING ACTIVITIES AND INHIBITORY ACTION IN RADIATION-INDUCED LIPID PEROXICATION

CHEN Honghong; HU Yuxing; ZHANG Yani; YANG Zhaohua; WANG Yihua; LUO Meichu; SUN Meizhen(Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200032)  
Effects of single molecular and double molecular substituted phenolic chelating agents on scavenging of superoxide anions and hydroxyl radicals and inhibition of rat liver mitochondria lipid peroxidation induced by irradiation were studied. The phenolic chelating agents were shown to different extent to scavenge oxygen free radicals and to protect against radiation-induced lipid peroxidations, and their half inhibition concentrations (IC50) on hydroxyl radicals generation and lipid perokidation were 1x10-6mol/L, which of scavenging of superoxide anions were 1x10-3mol/L. 7601(CBMIDA), 9501 and 9502 were the best among them. The free radical scavenging and antioxidant activities were close related to chemical structure and decorporated bioactivity.
【Fund】: 国家自然科学基金青年基金!39700039
【CateGory Index】: R14
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