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《Journal of Radiation Research and Radiation Processing》 2003-04
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Induction and protective effects of metallothionein under radiation exposure

WANG Jianlong (Laboratory of Environmental Technology, Institute of Nuclear Energy Technology, Tsinghua University, Beijing 100084) (National Laboratory of Environment Simulation and Pollution Control, Tsinghua University Beijing 100084)  
Metallothioneins (MT) are low-molecualr weight (about 6- 7ku) and cysteine-rich (30%) metal-binding proteins, and their synthesis can be induced by radiation exposure. Biological functions of MT include mainly micronutrient, storage, transportation and metabolism, resistance to ionizing radiations, scavenger of free radicals and metal detoxification. The paper gives a review on MT classification, MT genes structure, gene amplification and regulation, radiation induced synthesis of MT and the mechanisms, and protective effects of MT to ionizing radiations.
【Fund】: 国家自然科学基金(50278045)资助
【CateGory Index】: Q51
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