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Study on ultrastructural changes in thyroid gland of rats exposed to pulsed electromagnetic wave

ZHOU Xiaoguang ZENG Guiying REN Dongqing FANG Henghu SU Xiaoming HUANG Xiaofeng (Department of Radiation Medicine, Faculty of Military Prevention Medicine, Fourth Military Medical University, Xi'an 710032) (Electron Microscopic Center, Faculty of Preclinical Medicine,Fourth Military Medical University, Xi' an 710032)  
The work is to observe effects of PEMW (pulse electromagnetic wave) exposure on function and morphology of thyroid gland of rats. At different time points (24, 48, 96 and 192h) after exposure to PEMW (E=115kV m-1, 12000 pulses), radioimmunoassay was performed to observe the levels of thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodo- thyronine (T3) in sera of the male Sparague-Dawley rats. Optic microscopy and transmission electron microscopy (TEM) were used to observe structural changes of the thyroid gland at the time points. The T3、T4 and TSH in sera increased significantly, reaching a peak at 24h and decreasing gradually then. Although no obvious changes in the thyroid gland were observed under the optic microscope, some ultrastructral changes in the thyroid gland were found under the TEM. The ultrastructures were obviously changed at 12 h and aggravated until 48 h. In the experimented rats, dilatated endoplasmic reticulum gathered with lots of protein excretion, lipid droplet and heterochromatin gathered under the nucleus membranes were observed in follicular epithelial cells. These changes were palliated at 96 h but not recovered. PEMW can affect levels of hormones in sera and the hazard ultrastructual changes of thyroid gland. Endoplasmic reticulum is the main injured organelle.
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