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《Journal of Radiation Research and Radiation Processing》 2006-06
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Expression and localization of Smad4, Smad1 and Smad5 in testis of mice exposed to electromagnetic pulses

JI Xinxin HOU Wugang ZHAO Jie ZHAO Yong LI Wei ZHANG Yuanqiang (Department of Histology and Embryology, Fourth Military Medical University, Xi’an 710032)  
Changes in expressions of smad4, smad1 and smad5 in the spermatogenic cells of mice after whole-body exposure to electromagnetic pulse (EMP) were studied to elucidate possible mechanisms of the EMP-induced injuries. Twenty adult Balb/c mice were irradiated with 400kV/m EMP to the whole-body. Specimens were harvested on 1, 7, 14, 21and 28 days after the irradiation. Changes in cellular localizations and expressions of Smad4, Smad1 and Smad5 were examined by immunohistochemical ABC method. Quantitative analysis of the im- munostaining was made by an image analysis system. In the seminiferous tubules, the localization of Smad4, Smad1 and Smad5 in the EMP group were significantly different from the control group. The expression densities of smad4, smad1 and smad5 changed significantly on 1, 7, 14, 21and 28 days after irradiation. The study indicates that Smad4, Smad1, Smad5 and BMPs/Smad signal pathway may play an important role in the process of impairment and repair of mouse testis irradiated by EMP.
【Fund】: 国家自然科学基金(30370750);; 全军医药卫生科研基金(01MA183)资助
【CateGory Index】: R594.8
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【References】
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1 YANG Yang1 HOU Wugang2 ZENG Lihua3 ZHAO Jie2 LI Zhen2 ZHANG Yuanqiang21(Department of Dentistry and Clinical Medicine;Fourth Military Medical University,Xi’an 710032,China) 2(Department of Histology and Embryology,Fourth Military Medical University,Xi’an 710032,China) 3(Department of Radiation Medicine,Fourth Military Medical University,Xi’an 710032,China);The effects of electromagnetic pulses on the expression of TGF-βs in testis of mice[J];辐射研究与辐射工艺学报;2011-01
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Zhao Jie,Hou Wugang,Zhang Yuanqiang~*(Department of Histology and Embryology,The Fourth military Medical University,Xi'an 710032,China);IMPROVED METHOD TO EVALUATE SEMINIFEROUS EPITHELIUM STAGE IN MOUSE TESTIS[J];中国组织化学与细胞化学杂志;2006-02
2 HOUWugang ZHAO Jie ZHANG Yuanqiang ZENG Lihua GUOGuozhen (Department of Histology and Embryology, Fourth Military Medical University, Xi 'an 710032) (Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi'an 710032);Radiation effects of electromagnetic pulses on mouse blood-testis barrier[J];辐射研究与辐射工艺学报;2005-06
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【Co-citations】
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1 Luo Yaning;Ding Guirong;Chen Yongbin;Xu Shenglong;Wang Xiaowu;Department of Obstetrics and Gynecology,Tangdu Hospital of Fourth Military Medical University;;Effects of electromagnetic pulses on apoptosis and TGF-β3 expression of mouse testis tissue[J];中华劳动卫生职业病杂志;2014-04
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4 XU Kai1 HOU Wugang1 ZENG Lihua2 ZHAO Jie1 LI Zhen1 ZHANG Yuanqiang1 1(Department of Histology and Embryology,Fourth Military Medical University,Xi’an 710032,China) 2(Department of Radiation Medicine,Fourth Military Medical University,Xi’an 710032,China);Effect of electromagnetic pulses on the expression of occludin in testis of mice[J];辐射研究与辐射工艺学报;2011-05
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【Co-references】
Chinese Journal Full-text Database 6 Hits
1 JI Xinxin HOU Wugang ZHAO Jie ZHAO Yong LI Wei ZHANG Yuanqiang (Department of Histology and Embryology, Fourth Military Medical University, Xi’an 710032);Expression and localization of Smad4, Smad1 and Smad5 in testis of mice exposed to electromagnetic pulses[J];辐射研究与辐射工艺学报;2006-06
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