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The effects of electromagnetic pulses on the expression of TGF-βs in testis of mice

YANG Yang1 HOU Wugang2 ZENG Lihua3 ZHAO Jie2 LI Zhen2 ZHANG Yuanqiang21(Department of Dentistry and Clinical Medicine;Fourth Military Medical University,Xi’an 710032,China) 2(Department of Histology and Embryology,Fourth Military Medical University,Xi’an 710032,China) 3(Department of Radiation Medicine,Fourth Military Medical University,Xi’an 710032,China)  
In order to explore the expression and significance of transforming growth factor-β(TGF-β) super-family members TGF-β1,TGF-β3 and TGFβ-R1 in the testis of mice after whole-body exposure to electromagnetic pulse(EMP),twenty adult Balb/c mice were irradiated with EMP of 400 kV/m for 200 times to the whole body and other twenty adult Balb/c mice were sham irradiated in the same condition.Specimens were harvested on 1,7,14,21 and 28 days after irradiation.Changes in cellular localization and expression of TGF-β1,TGF-β3 and TGFβ-R1 were examined by immunohistochemical ABC method.Quantitative analysis of the immunostaining was made by an im-age analysis system.In the seminiferous tubules,the expression or localization of TGF-β1,TGF-β3 and TGFβ-R1 in the irradiated groups were significantly different from the control groups.These results indicate that TGF-β1,TGF-β3,TGFβ-R1 and the mediated signal pathway may play an important role in the process of impairment and repair of mouse testis irradiated by EMP.
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