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《Journal of Fujian College of Traditional Chinese Medicine》 2007-02
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Observation of Danshen Decoction on Improvement of Ischemical Reperfusion Injury of Skeletal Muscle in Rat Model

ZHANG Li,LU Li(Department of Orthopaedics and Traumatology,FCTCM,Fuzhou,Fujian 350108,China)  
To evaluate the effect of danshen decoction on ischemical reperfusion injury by swelling index and pathohistology observation.The left cremaster muscles of male SD rats received a standard diet and water were isolated and opened on the ventral side via an incision of the scrotum.The rats were randomly divided into two groups received an intraperitoneal injection of either danshen decoction or the same volume of phosphate buffered saline as a control.Three hours of ischemia was achieved by clamping the main vascular pedicle.Pathologic features of the cremaster muscle and swelling indexs were documented.The pathology slices and swelling indexs showed that danshen decoction can significantly reduced inflammation and neutrophil extravasation.Conclusion: Danshen decoction might improve swelling in the reperfused tissue,thereby reduce reperfusion injury.
【Fund】: 国家自然科学基金(30572401);; 福建省自然科学基金(C0510023);; 福建省高层次人才科研基金资助项目(1473)
【CateGory Index】: R274.32
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