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《Journal of Fujian University of Traditional Chinese Medicine》 2013-02
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Effects of Bushen Huoxue Decoction on Levels of IL-1β and TGF-β1 in Synovial Fluid of Knee Osteoarthritis Patients

XIU Zhongbiao,PAN Xigui(The First Affiliated Hospital,FUTCM,Fuzhou,Fujian 350004,China)  
Objective To observe the effects of Bushen Huoxue decoction on knee osteoarthritis(KOA) and explore its mechanism.Methods 42 KOA patients with kidney deficiency and blood stasis syndrome(58 knees) received Bushen Huoxu decoction,the knee functional scores were used to evaluate the re sults before the treatment,after one course of treatment and two course of treatment,the synovial fluid in knee joint was collected and the levels of IL-1β,TGF-β1 in synovial fluid were detected by double antibody sandwich ELISA method.Results After the treatment,the knee functional scores were significantly increased,the level of IL-1β was gradually decreased,the level of TGF-β1 was gradually increased,and the difference between groups was significant(P0.05).Conclusion Bushen Huoxue decoction can decrease the level of IL-1β,increase the level of TGF-β1 in synovial fluid,and improve the knee joint active function of KOA patients.
【Fund】: 福建省教育厅科技项目(JB09157)
【CateGory Index】: R274.9
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