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《Journal of Forensic Medicine》 2006-03
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Dissection of Cavernous Nerves in Rat and Model of Neurological Erectile Dysfunction

WANG Fei-Xiang1, ZHANG Ling-Li1, ZHU Guang-You2(1.Department of Forensic medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030,China; 2.Institute of Forensic Science, Ministry of Justice, P.R.China, Shanghai 200063,China)  
Objectives To identify rat cavernous nerve and establish a rat model of erectile dysfunction caused by injury of cavernous nerve. Methods Ten rats were undergone dissections. 30 experimental rats were randomized into 2 groups, cavernous nerve were identified by electrical stimulation. One month after surgery, rat models were evaluated by electrical stimulation. Results The anatomic structure of cavernous nerve in rats are highly similar to human beings, the erection can be evoked by stimulating cavernous nerves, and after cavernous nerve injury it can not be evoked(P0.05). Conclusion Because of the highly similarity of cavernous nerve between rats and human beings, so as the suitable price, rat should be used as the ideal ED experimental animal. The model of ED caused by cavernous nerve injury is reliable.
【CateGory Index】: D919
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