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《Journal of Forensic Medicine》 2008-05
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Changes of RyR_2 mRNA Expression in Rats Suffering from Acute Myocardial Ischemia

JIE Ya1,ZHU Shao-hua1,JIANG Yan-wei2,ZHANG Lei1,FAN Fan1 (1. Department of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China; 2. Tianjin Institute of Criminal Science and Technology,Tianjin 300193,China)  
Objective To investigate the changes of ryanodine receptor 2(RyR2) mRNA expression in rats suffering from acute myocardial ischemia. Methods SD rats were divided randomly into normal control group,myocardial ischemia group and sudden death group. The models of myocardial ischemia and sudden cardiac death were induced by intraperitoneal injection of hypophysine. The changes of RyR2 mRNA expression in cardiac sarcoplasmic reticulum(SR) of rats suffering from myocardial ischemia were detected by fluorescent RT-PCR technique. Results The levels of RyR2 mRNA in the myocardial ischemia group and sudden death group were significant lower than those in the control group(P0.05). Conclusion Myocardial ischemia may induce down-regulation of cardiac SR RyR2 mRNA expression.
【Fund】: 湖北省自然科学基金资助项目(2007ABA293)
【CateGory Index】: D919
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