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《Journal of Forensic Medicine》 2009-01
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Expression of Matrix Metalloproteinase-3 after Brain Contusion in Rats

GUO Xiao-chong1,2, LI Ru-bo1, LIANG Hong-xia1, WANG Fu-yuan1, WU Xu1 (1. Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China; 2. Key Lab of Laboratory Transgenic Animal of Liaoning Province, Department of Labora- tory Animal Science, China Medical University, Shenyang 110001, China)  
Objective To investigate the expression of matrix metalloproteinase-3 after brain contusion and its applicability for estimating the age of brain contusion. Methods Rats had been divided into three groups: control group, sham operation group and brain contusion group. The expression of matrix metallo- proteinase-3 at different time was detected by immunohistochemistry and Western blot. Results By the immunohistochemistry, no staining was observed in control and sham operation groups. The positive stain- ing of MMP-3 appeared 6 hours after contusion, increased gradually in 24 hours and peaked 5 days after contusion, then started to decrease, 14 days after contusion still could be observed. By the Western blot analysis, no expression of MMP-3 was detected in control and sham groups. The positive staining of MMP-3 appeared 6 hours after contusion, increased gradually and maximized 5 days after contusion, then started to decrease, 14 days after contusion still could be found. Conclusion Time-order expression of MMP-3 could be used for estimating the age of brain contusion in forensic pathology.
【Fund】: 辽宁省高等学校科研项目(2008828)
【CateGory Index】: D919
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